hrp0084p3-1187 | Thyroid | ESPE2015

The Benefits of Preterm Neonate Development by Early Replacement Therapy with Levothyroxine: Longitudinal Prospective Study

Ben-Skowronek Iwona , Wisniowiecka Magdalena

Background: In premature neonates hypothyroidism or thyroid sick syndrome is frequently diagnosed, which is a result of the immaturity of the gland itself and the hypothalamic–pituitary–thyroid axis. The necessity of rapid adaptation to extrauterine life, generation of high thermal energy, and accelerated development of the central nervous system is the cause of the increased demand for thyroid hormone.Objective and hypotheses: The aim of our s...

hrp0095p2-193 | Growth and Syndromes | ESPE2022

Spontaneous final adult height in patients with idiopathic short stature

Banaszak-Ziemska Magdalena , Niedziela Marek

Background: Idiopathic short status (ISS) is defined as a height more than two standard deviations (SD) below the mean for age and sex and population group without evidence of systemic, endocrine, nutritional, or chromosomal abnormalities. Children with ISS have normal birth weight and GH secretion.Aims: Aim of the study was to analyze the final adult height in a group of patients with idiopathic short stature.<p cla...

hrp0086rfc9.7 | Pathophysiology of Disorders of Insulin Secretion | ESPE2016

Chronotype and Type 2 Diabetes Risk in Preadolescents

Dumin Magdalena , O'Sullivan Katie , Van Cauter Eve , Koren Dorit

Background: An individual’s chronotype, or preference in the timing of sleep or food intake, may have metabolic implications. Late chronotype has been associated with higher body mass index (BMI) and hemoglobin A1c (HbA1c) in adults and greater BMI, portion sizes, and lower HDL cholesterol levels in adolescents.Objective and hypothesis: To examine associations between chronotype and risk factors for type 2 diabetes in children ages 10–13 years....

hrp0086rfc14.7 | Growth : Mechanisms | ESPE2016

GH Influences Plasma Fasting Adropin Concentration in Patients with Turner Syndrome

Wikiera Beata , Krawczyk Magdalena , Noczynska Anna , Daroszewski Jacek

Background: Increased adiposity and insulin resistance are conditions frequently observed nowadays. Many hormones are involved in the pathogenesis of the condition but therapeutic options we can offer to the patients are still scant. Each newly discovered peptide give us hope. Adropin (Ad) is a newly discovered metabolic hormone involved in energy homeostasis. This homeostasis is frequently disturbed in patient with Turner Syndrome (TS). Patient with Turner syndrome are unique...

hrp0082p1-d2-244 | Thyroid (1) | ESPE2014

Treatment of Graves’ Disease with Methimazole in Children Alters the Proliferation of Treg Cells and T Lymphocytes

Klatka Maria , Grywalska Ewelina , Wasiak Magdalena , Rolinski Jacek

Background: Graves’ disease (GD) is almost always the cause of hyperthyroidism in children. Studies carried out for recent years confirm an important role of T regulatory cells (Tregs) in the development of autoimmune diseases. However, the interactions between T-cell response and Treg proliferation in GD is still poorly understood.Objective and hypotheses: The aim of this research was the assessment of the in vitro proliferation of Treg ce...

hrp0084p2-226 | Bone | ESPE2015

Association between Oxidative Stress and Bone Turnover Markers in the Obese Children

Matusik Pawel , Olszanecka-Glinianowicz Magdalena , Chudek Jerzy , Malecka-Tendera Ewa

Background: Recent data have been showed that free radicals are involved in either bone resorption and atherosclerosis development in adults. In paediatric population the important risk factor for the early atherosclerosis development is obesity, which can be also associated with the disturb bone turnover.Objective and hypotheses: The aim of the study was to evaluate the interrelationship between oxidative stress and bone turnover markers in obese childr...

hrp0084p2-443 | Gonads | ESPE2015

Usefulness of 3D Ultrasonography for Assessment of the Morphology of the Ovary in Adolescents with Hyperandrogenism

Ben-Skowronek Iwona , Budzynska Elzbieta , Wozniak Magdalena , Wieczorek Pawel

Background: Polycystic ovary morphology (PCOM) in USG should not be identified with polycystic ovary syndrome (PCOS) and it is not a criterion for diagnosis of this syndrome in adolescents.Objective and hypotheses: Assessment of the usability of 3D ultrasonography in diagnostics of androgen excess disorders.Method: 40 girls aged 14–18 with hyperandrogenism were subjected to endocrinological examinations and transrectal USG of ...

hrp0084p3-1202 | Thyroid | ESPE2015

A Curious Case of Thyrotoxic Crisis and Lower Extremity Weakness in a 15 year-Old Female with Graves’ Disease

Dumin Magdalena , Afzal Khalid , Macmillan Carol , Koren Dorit

Background: Thyrotoxic crisis is a rare, emergent complication of paediatric hyperthyroidism. A rare neurological manifestation of thyrotoxicosis is thyroid myopathy.Objective and hypotheses: We report the case of a female teenager who presented to the Emergency Department with thyrotoxic crisis and lower extremity weakness. Our objective is to discuss the course of thyrotoxic crisis and review potential rare neurological manifestations of thyrotoxicosis...

hrp0086p2-p855 | Syndromes: Mechanisms and Management P2 | ESPE2016

The Usefulness of Magnetic Resonance Imaging of the Heart and Aorta in the Diagnostic Work-up in Girls with Turner Syndrome

Obara-Moszynska Monika , Rozmiarek Szymon , Lanocha Magdalena , Kociemba Anna , Rabska-Pietrzak Barbara , Janus Magdalena , Siniawski Andrzej , Mrozinski Bartlomiej , Niedziela Marek , Pyda Malgorzata

Background: Congenital heart defects are found in 50% of girls with Turner syndrome (TS). The evaluation of cardiovascular system is an important element in the diagnostic work-up of TS and is of particular significance of cardiologic monitoring, safety aspects of rGH treatment and any pregnancy planning.Objective and hypotheses: Assess the cardiovascular system in TS girls with magnetic resonance imaging of the heart and aorta (CMR and angioMR).<p c...

hrp0092p1-41 | Fat, Metabolism and Obesity | ESPE2019

Growth Arrest-Specific 6 (Gas6) Protein is Associated with Adiposity and Metabolic Syndrome in Obese Children and Adolescents

Zajdel-Cwynar Olimpia , Matusik Pawel , Olszanecka-Glinianowicz Magdalena , Malecka-Tendera Ewa

Introduction: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein produced by several types of cells including adypocytes and regulates their homeostasis. Previous studies indicate that Gas6 signaling may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. However, little is known about the clinical significance of the Gas6 system in childhood obesity. The aim of the study was t...