hrp0098fc7.5 | GH and IGFs | ESPE2024

Use of overnight GH sampling in the diagnosis of growth disorders in children: neuroimaging findings and response to treatment

Mainieri Francesca , Cerbone Manuela , Caiulo Silvana , Gan Hoong-Wei , Tulsidas Dattani Mehul

Background: The diagnosis of GH deficiency is challenged by the suboptimal accuracy of GH stimulation tests. Overnight GH sampling (OGS) may be useful in the diagnosis of growth disorders.Objectives: To establish if 1) the reduced number of spontaneous overnight GH profile peaks (SOGPP) is associated with hypothalamo-pituitary (H-P) abnormalities on MRI, 2) these children benefit from GH treatment....