hrp0084p3-1170 | Thyroid | ESPE2015

Topical Iodine Induced Thyrotoxicosis in a Newborn with Giant Omphalocele

Malhotra Sonali , Kumta Shilpa , Motaghedi Roja

Background: Thyrotoxicosis in neonates is a life-threatening condition that can be associated with lasting neurologic problems. Most cases are seen in neonates born to mothers with GravesÂ’ disease in which thyroid stimulating immunoglobulin (TSI) is transferred to the foetus and results in hyperthyroidism. Hypothyroidism due to topical iodine use has been reported in neonates, but thyrotoxicosis has never been described in this age, while in adults is a known entity. We h...

hrp0084p3-1183 | Thyroid | ESPE2015

Effect of Marijuana Use on Thyroid Function and Autoimmunity

Malhotra Sonali , Homel Peter , Motaghedi Roja

Background: Cannabis use has been legalised in four states in USA. However, endocrine effects of marijuana use are largely unknown. Published experiments on animals have suggested that acute cannabis exposure may lead to suppressed thyroid function, but human studies are limited. Of interest, some studies have shown that cannabis has immunomodulatory effects.Objective and hypotheses: We carried out a cross sectional analysis of data by National Health an...

hrp0097fc3.6 | Fat, metabolism and obesity 1 | ESPE2023

Impact of Setmelanotide on Future Metabolic Syndrome Risk in Pediatric Patients With Bardet-Biedl Syndrome

Haqq Andrea , Poitou Christine , K. Chung Wendy , Iqbal Anoop , Forsythe Elizabeth , Malhotra Sonali , Touchot Nicolas , Clément Karine , Argente Jesús

Background: Children with metabolic syndrome carry an increased risk for development of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in adulthood. Patients with rare syndromic obesity, such as Bardet-Biedl syndrome (BBS), experience early-onset, severe obesity, which may convey an increased risk for developing obesity-related comorbidities and metabolic syndrome later in life. In clinical trials, treatment with the melanocortin-4 receptor a...

hrp0095rfc4.2 | Fat, Metabolism and Obesity | ESPE2022

Effect of Setmelanotide Treatment in Children and Adolescents With Proopiomelanocortin (POMC) Deficiency, Leptin Receptor (LEPR) Deficiency, and Bardet-Biedl Syndrome (BBS)

Argente Jesús , Kühnen Peter , M. Haqq Andrea , Wabitsch Martin , K. Chung Wendy , van den Akker Erica , Á. Martos-Moreno Gabriel , Mohamed Iqbal Anoop , Forsythe Elizabeth , Dubern Béatrice , Malhotra Sonali , Yuan Goujun , Touchot Nicolas , Dollfus Hélène , Farooqi Sadaf , Clément Karine

Background: The melanocortin-4 receptor (MC4R) pathway is a key regulator of energy balance and satiety. Variants in genes upstream of MC4R encoding leptin receptor (LEPR), proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1(PCSK1) and those involved in Bardet-Biedl syndrome (BBS) can impair MC4R pathway signaling. Clinically, these variants are characterized by hyperphagia (Pathologic insatiable hunger) and early-onset, severe obesity. E...