ESPE Abstracts

Background: Synthetic glucocorticoid (GC) form crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). However, some patients reveal GC resistance with unknown mechanism. We have previously shown that reciprocal regulation of the GC metabolizing enzymes, 11beta-hydroxysteroid dehydrogenase types 1 and 2 (11b-HSD1 and 11b-HSD2) is associated with GC sensitivity/resistance in ALL at diagnosis. 11b-HSD1 predominantly regenerates active GC f...

Background: Medulloblastoma accounts for about 10% of pediatric brain tumor, and about 60 to 100 cases occur in Japan per year. After tumor removal, chemotherapy and radiation therapy including craniospinal irradiation (CSI) are performed. Since the irradiation range of CSI includes hypothalamus, pituitary gland, thyroid, ovaries, and spine, it is known that endocrine deficiency and growth disorders are frequent as late effects. In this study, we aim to highli...