hrp0082p3-d3-942 | Puberty and Neuroendocrinology (1) | ESPE2014

A Severe LHRH-Independent Precocious Puberty in a 26-Month-Old Girl with a Clinical Diagnosis of McCune–Albright Syndrome

Flader Maciej , Latos-Bielenska Anna , Kapczuk Karina , Mankowski Przemyslaw , Malecka Elzbieta , Niedziela Marek

Background: Gonadal hyperfunction is the most frequent endocrine dysfunction in females with McCune–Albright syndrome (MAS), and precocious puberty (PP) is usually the first manifestation of MAS in children.Objective and hypotheses: The optimal pharmacologic treatment of PP in girls with MAS has not been yet identified and new therapeutic options like anti-estrogen should be taken under consideration especially in patients with extreme high estradio...