hrp0098p1-65 | Growth and Syndromes 1 | ESPE2024

Cardiovascular autonomic dysfunction and sleep abnormalities in children with Prader-Willi syndrome

Debs Rachel , Diene Gwenaëlle , Cortadellas Julie , Molinas Catherine , Kermorgant Marc , Tauber Maïthé , Pavy Le Traon Anne

Purpose: Prader-Willi syndrome is a rare genetic neurodevelopmental condition characterized by cognitive disabilities, behavioural problems, hypothalamic dysfunction with obesity and sleep disorders. A few studies have reported autonomic nervous system dysfunction. Our aim was to investigate in details dysautonomia combining sleep studies and standard autonomic testing in children with Prader-Willi syndrome regularly followed.Met...