ESPE Abstracts

Vascular complications continue to be a major concern for young people with type 1 diabetes (T1D), who have a decreased life expectancy, by 8-16 years, compared to the background population. Diabetic nephropathy and cardiovascular disease are main contributors to morbidity and mortality in people with T1D. Thus, early detection and prevention of complications are of paramount importance to improve their long-term prognosis.Although HbA1c is a major risk ...

Cardiovascular disease (CVD) remains the main cause of morbidity and mortality in individuals with type 1 diabetes (T1D). Although the clinical manifestations of CVD are almost exclusively observed in adult life, their incidence represents the result of a long subclinical disease process, which is largely driven by potentially modifiable risk factors, including not only hyperglycaemia but also dyslipidaemia, hypertension, obesity, insulin resistance, lifestyle habits. In indiv...

Aims: To examine growth, body composition and glucose metabolism during childhood in children born small for gestational age (SGA).Methods: Single centre cohort study of 150 children (63 boys), identified from newborn records as being born SGA (birth weight SDS <−1.5) and assessed between the age of 4 and 7 years. Data collected included: anthropometric parameters (height, weight, BMI: transformed into age- and sex-adjusted SDS), lean and fat m...

Background: Perinatal factors seem to influence the onset of puberty. There is some evidence suggesting that being born small for gestational age (SGA) is associated with early puberty, whereas the effect of large size at birth on timing of puberty is not clear.Objective and hypotheses: To evaluate the timing of puberty in children born SGA and large for gestational age (LGA) compared to children born appropriate for gestational age (AGA).<p class="a...

Background: Variable rate intravenous insulin infusion (VRIII) is commonly used in unwell patients with diabetes and complex nutritional needs. However, frequent blood glucose monitoring with infusion rate adjustment gives rise to significant safety concerns and is extremely resource intensive. Fully closed-loop (FCL) systems are promising technological advancements in diabetes management. It comprises of continuous glucose monitoring and a control algorithm t...