hrp0084p2-226 | Bone | ESPE2015

Association between Oxidative Stress and Bone Turnover Markers in the Obese Children

Matusik Pawel , Olszanecka-Glinianowicz Magdalena , Chudek Jerzy , Malecka-Tendera Ewa

Background: Recent data have been showed that free radicals are involved in either bone resorption and atherosclerosis development in adults. In paediatric population the important risk factor for the early atherosclerosis development is obesity, which can be also associated with the disturb bone turnover.Objective and hypotheses: The aim of the study was to evaluate the interrelationship between oxidative stress and bone turnover markers in obese childr...

hrp0092p1-41 | Fat, Metabolism and Obesity | ESPE2019

Growth Arrest-Specific 6 (Gas6) Protein is Associated with Adiposity and Metabolic Syndrome in Obese Children and Adolescents

Zajdel-Cwynar Olimpia , Matusik Pawel , Olszanecka-Glinianowicz Magdalena , Malecka-Tendera Ewa

Introduction: Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein produced by several types of cells including adypocytes and regulates their homeostasis. Previous studies indicate that Gas6 signaling may be involved in the pathogenesis of obesity and its complications, including systemic inflammation and insulin resistance. However, little is known about the clinical significance of the Gas6 system in childhood obesity. The aim of the study was t...

hrp0082p2-d3-444 | Growth Hormone (2) | ESPE2014

Baseline Body Composition of Children with Short Stature Diagnosed for GH Deficiency

Matusik Pawel , Barylak Aleksandra , Cholewka Patrycja , Klesiewicz Marta , Klos Karolina , Stasiulewicz Martyna , Cetera Maria , Malecka-Tendera Ewa

Background: Severe GH deficiency (GHD) is associated with significant body composition abnormalities. However there is no data assessing initial body composition parameters in the children with partial GHD.Objective and hypotheses: Study objective was initial body composition assessment in the short stature children diagnosed for GHD.Method: 54 consecutively diagnosed for GHD short statured children (40 boys) in the mean age 10.83&...

hrp0082p2-d3-497 | Endocrine Oncology | ESPE2014

Gonadal Tumor in 46,XY and 45,X/46,XY Female Patients: One Clinical Center Experience

Gawlik Aneta , Antosz Aleksandra , Kudela Grzegorz , Drosdzol-Cop Agnieszka , Zachurzok Agnieszka , Matusik Pawel , Kaminska Halla , Koszutski Tomasz , Malecka-Tendera Ewa

Background: The incidence of gonadal tumor development varies significantly between subsets of patients with disorder of sex development (DSD). In some female patients with Y chromosome too early gonadectomy is perceived as overtreatment.Objective and hypotheses: The aim of the study was to analyze the gonadal tumor incidence in DSD female patients with 45,X/46,XY or 46,XY.Method: 15 patients, managed at single institution between ...