hrp0098p1-282 | Sex Endocrinology and Gonads 3 | ESPE2024

Estrogen and progesterone in immune dysfunction at childhood follow up of preterm infants

Stewart Philip , Byrne Dearbhla , Branagan Aoife , Isaza-Correa Johana , Kelly Lynne , Meehan Judith , Molloy Eleanor

Background and Aims: Infants born prematurely have increased risk of multi-organ dysfunction and death throughout their lives. Males are particularly higher risk and susceptible to the adverse effects of infection related inflammation with poorer clinical outcomes. Immune function, hormone exposure and genetic factors play contributory roles. Physiological concentrations of female hormones hypothesised to have a role in immune development, could affect the exp...