ESPE Abstracts

We have explored the role of local epithelial GHR signaling in regulating the tissue microenvironment. Despite declining circulating pituitary GH with age, colon epithelial DNA damage and aging trigger local non-pituitary growth hormone (npGH) expression. We showed that accumulated DNA damage, a driving force for age-related pathologies including neoplasia, may result from local npGH- mediated defective DNA damage repair (DDR) and build-up of unrepaired DNA damage resulting in...

Background: The molecular genetics of isolated hypogonadotropic hypogonadism (IHH) has been a subject of interest and recent discoveries. Multiple genetic variants with x-linked and autosomal inheritance are involved in the regulation of the hypothalamic pituitary gonadal axis.Objective and hypotheses: We undertook an extensive genetic evaluation to elucidate a possible genetic aetiology in two brothers with clinical and biochemical evidence of IHH. We h...