hrp0084p1-162 | Miscelleaneous | ESPE2015

Congenital Hypothyroidism: Reduction in the Female to Male Ratio Following the Decrease of the TSH Cut-off Point Used for Neonatal Screening

Voutetakis Antonis , Giogli Vassiliki , Platis Dimitris , Gika Anna , Iliadi Alexandra , Mengreli Chrysanthi , Chrousos George , Kanaka-Gantenbein Christina , Girginoudis Panagiotis

Background: Since the initiation of neonatal screening-programs for congenital hypothyroidism (CH) in the 1970’s, an increase in the incidence of CH has been observed. This change has been attributed to the gradual use of lower TSH cut-offs that lead to the detection of milder cases of CH. Based on currently used screening cut-offs, CH occurs in approximately 1:2 000 to 1:4 000 newborns, varying by geographic location and ethnicity. A female predominance, approaching a 2:...

hrp0084p1-127 | Thyroid | ESPE2015

Transient vs Permanent Congenital Hypothyroidism: The Use of Baseline Characteristics and Long-Term Data Can Help Formulate a Practical Prognostic Algorithm

Giogli Vassiliki , Kanaka-Gantenbein Christina , Chouliaras George , Arditi Jessica-Debora , Gika Anna , Iliadi Alexandra , Platis Dimitris , Kyritsi Eleni Magdalini , Karkalousos Petros , Karikas George-Albert , Mengreli Chrysanthi , Chrousos George , Girginoudis Panagiotis , Voutetakis Antonis

Background: Implementation of neonatal screening programs for congenital hypothyroidism (CH) has reduced related nosologies and has eradicated CH-associated mental impairment. With the decrease of the TSH cut-off limits employed to avoid false negative results, milder cases of CH are diagnosed. Obviously, in a number of patients, especially among milder CH cases, thyroid dysfunction is transient. The diagnosis of transient vs. permanent CH is established in time. No specific p...