hrp0098p1-126 | Diabetes and Insulin 3 | ESPE2024

Non-invasive techniques to detect early signs and determinants of diabetic peripheral neuropathy in children with type 1 diabetes.

Eilers Miriam , Fellmann Metsnanat , Wurster Janina , Meier Sandro , Lütschg Jürg , Oberhauser Sarah , Heldt Katrin , Philip Broser , l'Allemand Dagmar

Background: There is an urgent need for better detection of early subclinical manifestations of microvascular complications of diabetes such as peripheral neuropathy (DPN), which already occur in children. The gold standard for the diagnosis of DPN is the measurement of nerve conduction velocity (NCV), which, however, can only detect changes in the large myelinated fibres. At the initial stage of DPN, small, unmyelinated nerve fibres are damaged. High-resoluti...