hrp0098p1-144 | Fat, Metabolism and Obesity 3 | ESPE2024

Age different in anti-obesity treatment targeting BAT with Ang1-7

Mori Jun , Kawabe Yasuhiro , Morimoto Hidechika , Inoue Nozomi , Miyagaki Satoshi , Yamaguchi Mihoko , Sugimoto Satoru , Okamura Takuro , Hamaguchi Masahide , Fukui Michiaki

Background: Brown adipose tissue (BAT) was thought to exist only from birth to infancy and not in adults. However, it has recently been found to be present in adults as well, drawing significant attention as a target for anti-obesity drugs due to its characteristic of energy expenditure independent of exercise. ACE2 converts Angiotensin II (AngII) to Angiotensin 1-7 and antagonizes the ACE/AngII system through Mas receptor. We have previously reported that adm...