hrp0092p3-190 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

Structural Pituitary Abnormality and Dysfunction Associated with Charge Syndrome

Karachaliou Feneli , Skarakis Nikitas , Mitrogiorgou Marina , Simatou Aristophania , Papaevangelou Vassiliki

Background: CHARGE is an autosomal-dominant syndrome which includes a variable combination of coloboma of the eye, heart malformations, atresia of the choanae, retardation of growth and development, and genital and ear abnormalities CHARGE syndrome has rarely been associated with anterior pituitary dysfunction and with structural abnormalities of the pituitary gland only twice. We report the case of a child with CHARGE association and congenital hypopituitaris...

hrp0092p1-74 | GH and IGFs | ESPE2019

Recombinant GH Treatment in Child with Pseudopseudohypoparathyroidism Associated with Growth Hormone Deficiency

Karachaliou Feneli , Skarakia Nikitas , Mitrogiorgou Marina , Simatou Aristophania , Peppa Melpomeni , Papaevangelou Vassiliki

Background: Pseudopseudohypoparathyroidism (PPHP) is a rare variant of pseudohypoparathyroidism (PHP) type I, with typical anatomical abnormalities known as Albright's hereditary osteodystrophy (AHO)(short stature, brachydactyly particularly involving metacarpals and metatarsals, round face, stocky build, ectopic ossifications and a number of possible associated defects), but with normal calcium, phosphate and PTH levels and normal response to exogenous PT...

hrp0092p2-40 | Bone, Growth Plate and Mineral Metabolism | ESPE2019

Reduced Bone Mineral Density in Children with Inflammatory Bowel Disease without Exposure to Corticosteroid Treatment

Mitrogiorgou Marina , Karachaliou Feneli , Skarakis Nikitas , Simatou Aristophania , Peppa Melpomeni , Fessatou Smaragdi , Papaevangelou Vassiliki

Objectives: Bone mineral density is reduced in children and adolescents with inflammatory bowel disease (IBF). The exact cause of this reduction is not known and is often attributed to corticosteroid use. The aim of the study was to evaluate bone mineral density in children with IBF without previous corticosteroid exposure.Methods: Twelve children aged 8-17years with IBF (8 with Crohn's disease and 4 with ulcerative ...

hrp0092p2-214 | Multisystem Endocrine Disorders | ESPE2019

Celiac Disease and Endocrine Autoimmunity in Children and Adolescents

Mitrogiorgou Marina , Karachaliou Feneli , Karalexi Maria , Georgantzi Maria , Kontaki Helen , Foukas Periklis , Triantafyllou Konstantinos , Fesssatou Smaragdi

Objectives: Celiac disease (CD) is a life-long inflammatory disease of the gastrointestinal tract that affects genetically susceptible individuals and is associated with several autoimmune diseases. The aim of the study was to evaluate the prevalence of coexistent autoimmune endocrine disorders in children and adolescents diagnosed with CD.Patients and Methods: Children diagnosed with CD in the Paediatric Gastroenterolog...