hrp0094p1-189 | Pituitary B | ESPE2021

Dimensional changes in structures of craniofacial and brain in precocious puberty: Developmental surrogate markers of the brain as a secondary sex characteristic in puberty

Karaoglan Murat , Damar Cagri ,

Background/Aim: Sex hormones drive organizational and activational changes in craniofacial structures and various regions of the brain and establish a sexual dimorphism in the re-shaping of the brain and related structures during puberty. Although the evolutionary approach, which accepts the brain and related structures as secondary sex characteristics since they are target organs for sexual selection, increases awareness of the role of sex hormones in sex-spe...

hrp0092lb-28 | Late Breaking Posters | ESPE2019

The Volumetric Changes in the Olfactory Bulb Depend on Body Mass Index

Karaoglan Murat , Colakoglu Er Hale

Background/Objective: Energy balance is preserved through the exchange between body weight and adipose tissue across the multi-faceted complex network that is composed of the sensorial, metabolic, and neuroendocrine circuits. Olfactory control of the process is maintained through the central structures that include the hypothalamic-pituitary axis, together with the interplay between the olfactory bulbus (OB) and adipose tissue. Although the interaction of the ...

hrp0089p3-p148 | Fat, Metabolism and Obesity P3 | ESPE2018

Investigation of Pubertal Effect on Thyroid Volume and IGF-1 Changes in Morbid Obese Children

Karaoglan Murat , Balci Onur , Keskin Mehmet

Context: Thyroid growth and insulin like growth factor-1 (IGF-1) change depending on pubertal status and body mass index (BMI). The previous studies have reported some inconsistent results on association between thyroid volume (TV) and IGF-1 in terms of puberty and obesity.Objective: The aim of present study is to investigate pubertal effect of on TV and IGF-1 in morbid obese children.Design: The study population consisted of 250 c...

hrp0084p3-797 | DSD | ESPE2015

Screening for Y Microdeletions in Patients with Hypergonadotropic Hypogonadism due to Disorder of Sexual Development

Karaoglan Murat , Keskin Mehmet , Keskin Ozlem

Introduction: Hypergonadotropic hypogonadism is mainly characterised by streak or dysgenetic gonads. It is primer gonadal insufficiency which occurs as a result of chromosome abnormalities, gonad developmental and steroid synthesis defects. However, Y microdeletions associated hypergonadotropic hypogonadism due to disorder of sexual development has been reported, there are no many studies. Moreover, it is not known enough to contribution for development of sexual ambiquity. Ai...

hrp0094p1-177 | Growth Hormone and IGFs B | ESPE2021

Immunogenicity of recombinant growth hormone and relationship its growth-promoting effect in the children with short stature

Karaoglan Murat , Isbilen Elif , Keskin Mehmet ,

Background/Aim: Although there are many well-known components that affect the growth response to recombinate growth hormone (rGH), its effect on total height gain is still not fully predictable. Current knowledge on the relationship between growth response to rGH and its immunogenicity is limited. The aim of the study was to reveal its relationship with the antibody formation against rGH and growth-promoting effect.Materials and Methods:...

hrp0094p2-269 | Growth hormone and IGFs | ESPE2021

Immunogenicity of recombinant growth hormone therapy in the children with short stature and consequences on growth-promoting effect

Karaoglan Murat , Isbilen Elif , Keskin Mehmet ,

Background/Aim: Although there are many well-known components that affect the growth response to recombinant growth hormone (rGH), its effect on total height gain is still not fully predictable. A limited number of studies have been reported revealing up-to-date data on the relationship between immunogenicity and growth-promoting effects of rGH. The study aimed to examine the antibody formation against rGH and its consequences on growth-promoting effect in chi...

hrp0097p2-228 | Multisystem Endocrine Disorders | ESPE2023

Evaluation Of Bone Health And Endocrine Functions İn Children With Mucopolysaccharidosis

Albayrak Serpil , Karaoglan Murat , Keskin Mehmet

Introduction: Mucopolysaccharidoses (MPS) are lysosomal storage diseases. The frequency of endocrinological problems such as osteoporosis and hypothyroidism among children with MPS is not known and there are limited studies. In this study, the clinical findings, bone health and other endocrine functions of patients with MPS diagnosis and access to current treatments were retrospectively evaluated.Materials and Methods:Th...

hrp0092p1-112 | Pituitary, Neuroendocrinology and Puberty | ESPE2019

The Relationship between the Olfactory Bulb and Precocious Puberty:From Nose to Pituitary

Karaoglan Murat , Er Hale , Kaplan Emel , Keskin Mehmet

Background/Objective: The olfactory bulb (OB) and pubertal development have a close relationship as they share a common ontogenetic origin. The aim of this study is to analyze the potential relationship between the precocious puberty in girls as a sign of early pubertal timing and their OB volume as an indicator of its functional activity.Design: In the study group (n=125), OB volume, pituitary height, body ...

hrp0092p2-288 | Thyroid | ESPE2019

The Most Frequently Seen Reason of Congenital Hypothyroidism: Iodine Loading

Keskin Mehmet , Colak Berat , Kaplan Emel H.A. , Karaoglan Murat

Objective: Congenital hypothyroidism; currently, it is one of the most common causes of preventable mental retardation in children. Thyroid dysgenesis, thyroid hormone production and efficacy disorders or temporary hypothyroidism can be seen with the tables. In this study; The aim of this study was to evaluate the etiology and prognosis of congenital hypothyroid patients guided by national screening and neonatal centers. In this way; Our aim is to produce the ...

hrp0089p1-p086 | Diabetes & Insulin P1 | ESPE2018

Coincidence of Newly Diagnosed Type 1 Diabetes Mellitus with Enteroviruses and Respiratory Tract Viruses

Karaoglan Murat , Eksi Fahriye , Keskin Mehmet , Karaoglan İlkay

Background: Viruses, which trigger and promote islet cell destruction, cause type 1 diabetes mellitus (T1DM). However, the existence of a cause-and-effect relationship is under debate. The aim of this study was to investigate sero-epidemiological and molecular evidence of enteroviruses and respiratory viruses in patients with newly diagnosed T1DM during cold season.Methods: This study included 40 children with newly diagnosed T1DM and 30 healthy children...