hrp0092lb-8 | Late Breaking Posters | ESPE2019

Detection of Cardiomyopathy in Egyptian Children and Adolescents with Longstanding Obesity Using Cardiac Marker NT-pro PNB and Speckled Tracking Echocardiography

Hafez Mona , Musa Noha , Fakhry Antoine , ELMougy Fatma , ELShennawy Hala

Introduction: Obesity is considered a major risk factor for developing cardiovascular morbidity and mortality. Obesity affects the structure and function of the heart mainly by causing increased blood volume, elevated cardiac output, left ventricular (LV) hypertrophy, and LV diastolic dysfunction. All of which can play a role in causing heart failure.Objective: This cross-sectional study aimed to evaluate the effect of l...

hrp0092lb-17 | Late Breaking Posters | ESPE2019

Assessment of Urinary Podocalyxin as a Marker of Glomerular Injury in Obesity Related Kidney Disease in Obese Children and Adolescents compared to urinary Albumin-creatinine ratio

Hassan Mona , Musa Noha , Ramzy Tarek , Hamdy Ahmed

Introduction: Epidemiological data suggest that obesity was associated with increased risk of renal injury in children.Objective: To assess urinary podocalyxin in obese children and adolescents as a marker of obesity related kidney disease (ORKD) compared to urinary albumin creatinine (A/C) ratio as the standard marker of glomerular injury.Methodology: This case-control study inclu...

hrp0089p1-p091 | Diabetes & Insulin P1 | ESPE2018

Screening for T2D in High Risk Egyptian Children and Adolescents Using Strip HbA1c and OGTT

Hafez Mona , Musa Noha , Mansour Mona , Hamdy Heba

Background: The prevalence of type 2 diabetes (T2D) is significantly increased in pediatric population, which is affected by obesity worldwide. The progression of insulin resistance to T2D in obese children has been shown to be faster than in adults. Therefore, screening for T2D seems meaningful especially in high risk groups such as children and adolescents with obesity, family history of T2D, and those with clinical features of insulin resistance (hypertension, dyslipidemia,...

hrp0089p2-p092 | Diabetes & Insulin P2 | ESPE2018

Hypertriglyceridemia in Type 1 Diabetes Children During Diabetic Ketoacidosis; Relation to DKA Severity and Glycemic Control

Fawaz Lubna , Musa Noha , AbdelAtty Sahar , Nassef Ahmed

Background: Diabetic ketoacidosis (DKA) is a common, life-threatening complication of type 1 diabetes (T1D). Insulin deficiency impairs lipoprotein lipase (LPL) resulting in elevated serum triglycerides (TG) that usually normalize after establishing IV insulin.Objectives: To study the prevalence of hypertriglyceridemia during DKA in T1D patients and assess its relation to DKA severity and glycemic control after 3 months.Methodology...

hrp0086p1-p240 | Diabetes P1 | ESPE2016

Effect of Vitamin D Supplementation on Lipid Profile in Vitamin D Deficient T1D Patients with Dyslipidemia

Hafez Mona , Musa Noha , Sharaf Sahar , Wahab Nehal Abdel

Background: It was suggested that vitamin D has both direct and indirect effects on modifying the lipid profile in patients with diabetes through its regulatory action that increases the activity of lipoprotein lipase in adiposity.Objective and hypotheses: To detect the relationship between serum 25(OH) D and lipid profiles in patients with T1D and dyslipidemia and to study the effect of vitamin D supplementation on lipid profiles of vitamin D deficient ...

hrp0082p3-d1-633 | Adrenals & HP Axis | ESPE2014

Steroid 11β Hydroxylase Deficiency in Egyptian Children

Musa Noha , Ghali Isis , Farag Sara , Amin Maha , Hafez Mona

Background: Congenital adrenal hyperplasia (CAH) is one of the most common inherited endocrinal disorders. Steroid 11β hydroxylase deficiency (11βOHD) is the 2nd most common form of CAH. It is a rare AR disorder caused by CYP11B1 mutations with an incidence of 100 000–200 000 in overall population.Objective and hypotheses: To detect 11β hydroxylase deficiency in patients presenting with clinical manifestations and hormonal findings su...

hrp0084p3-739 | Diabetes | ESPE2015

Assessment of Quality of Life in Adolescents with Type 1 Diabetes; a Pilot Study

Hassan Mona , Musa Noha , Hay Rehab Abdel , Fathy Ashgan

Background: Diabetes as a disease and its treatment can have a profound effect on the quality of life (QoL) in terms of social and psychological well-being as well as physical ill health. Current goals of diabetes management focus on optimising metabolic control, along with preserving a good QoL.Aims and objectives: To assess QoL in adolescents with type 1 diabetes (T1D) at the Diabetes Endocrine and Metabolism Pediatric Unit at Cairo University.<p c...

hrp0084p3-745 | Diabetes | ESPE2015

Vitamin D Status in Egyptian Children with T1D and the Role of Vitamin D Replacement on Glycaemic Control

Hafez Mona , Hassan Mona , Sharaf Sahar , Musa Noha , Sameh Sally

Background: Many epidemiological studies have found high prevalence of vitamin D deficiency in children with type 1-diabetes mellitus (T1D). 1,25(OH)2D is a potent immune-modulator that also enhances the production and secretion of several hormones, including insulin. The association of low serum 1,25(OH)2D levels with high glucose level and diminished insulin sensitivity suggests that vitamin D may modulate insulin metabolism.Aim and objectives: To scre...

hrp0084p3-856 | Fat | ESPE2015

Relationship between Visceral Obesity and Plasma Fibrinogen in Obese Children

Hafez Mona , Masry Sahar El , Musa Noha , Fathy Marwa , Hassan Mona , Hassan Nayera , Tareef Mahmoud , Husseiny Mohamed El

Background: The prevalence of obesity in children and adolescents has increased significantly worldwide with an alarming rise of its co-morbidities. The excess of visceral adipose tissue is associated with hypertension, prothrombotic and pro-inflammatory states leading to cardiovascular diseases.Aim of the study: To find possible associations between visceral obesity and plasma fibrinogen, as one of the cardiovascular risk factors, in obese children....

hrp0084p3-582 | Adrenals | ESPE2015

Rapid Molecular Diagnosis of CAH by Strip Hybridisation Assay in DEMPU

El-Mougy Fatma , Hafez Mona , Atty Sahar Abdel , Ibrahim Amany , Mehawed Hend , Musa Noha , Ekladious Sherif , Elsharkawy Marwa , Abdullatif Mona , Afif Alaa , Baz Heba El

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder in which more than 90% of CAH cases are caused by mutations of the 21-hydroxylase (CYP21A2) gene.Objective and hypotheses: To determine the mutational spectrum in Egyptian CAH patients attending Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU) including family members of CAH patients.Method: The use of reverse hybridization assay for the mol...