hrp0084p3-1130 | Puberty | ESPE2015

Clinical Features and Pubertal Timing in Girls with Premature Adrenarche

Celik Sevinc , Kirmizibekmez Heves , Mutlu Rahime Gul Yesiltepe , Yildiz Feyza

Background: Premature adrenarche is defined as the development of axillary and/or pubic hair in association of the DHEA-S concentrations >108.4 nmol/l (40 μg/dl) before the age of eight in girls.Objective and hypotheses: This retrospective study aimed to investigate the clinical presentation, metabolic status, growth velocity and pubertal timing of girls with premature adrenarche.Method: Medical records of 117 patients wer...

hrp0082p2-d3-555 | Puberty and Neuroendocrinology (2) | ESPE2014

Tamoxifen-Induced Hirsutism: an Unusual Side Effect in a 5 Years Old Girl with Mccune–Albright Syndrome

Kirmizibekmez Heves , Mutlu Rahime Gul Yesiltepe , Dursun Fatma , Isguven Sukriye Pinar

Background: McCune–Albright syndrome is a rare disorder defined as the triad of peripheral precocious puberty, café-au-lait skin pigmentation and fibrous dysplasia of bone, caused by mutation of the gene GNAS1, resulting in autonomous endocrine hormone excess.Objective and hypotheses: This is the first pediatric case of hirsutism due to tamoxifen, a selective estrogen receptor modulator.Case report: A 53/12 yea...

hrp0082p3-d3-788 | Fat Metabolism & Obesity (2) | ESPE2014

Erythrocyte Sedimentation Rate and CRP Levels in Childhood Obesity

Ersu Dilek Ozcelik , Seren Lale , Mutlu Rahime Gul Yesiltepe , Kirmizibekmez Heves

Background: Childhood obesity is one of the most important public health problems at 21st century. Obesity is an inflammatory process that leads to the impairment of health. Increasing prevalence of obesity will be a worldwide problem in the next generation, leading to serious health care and economical burden.Objective and hypotheses: The aim of this study was to investigate the relationship between childhood obesity and erythrocyte sedimentation rate a...