hrp0084p2-576 | Thyroid | ESPE2015

Relationship between Cord Blood Phthalates and Maternal and Neonatal Thyroid Functions

Ozsoylu Serkan , Akin Leyla , Gunes Tamer , Kendirci Mustafa , Narin Figen , Kurtoglu Selim

Background: Phthalates are industrial chemicals extensively used as plasticizers in a variety of commercial products. Di-(2-ethylhexyl) phthalate (DEHP) is one of the most frequently used phthalates. DEHP is readily metabolized to mono-(2-ethylhexyl) phthalate (MEHP), which is more toxic than its parent compound. There are some animal and in vitro studies suggesting that phthalates can disrupt hypothalamus-pituitary-thyroid axis.Objective and hy...

hrp0082p1-d3-229 | Reproduction (2) | ESPE2014

The Role of Bisphenol A in Etiopathogenesis of Polycystic Ovary Syndrome in Adolescent Girls

Akin Leyla , Kendirci Mustafa , Narin Figen , Kurtoglu Selim , Saraymen Recep , Kondolot Meda , Ozkan Kocak Selda , Hatipoglu Nihal , Elmali Ferhan

Background: Polycystic ovary syndrome (PCOS) is a common endocrinological disorder of unclear etiopathogenesis characterized by hormonal and reproductive abnormalities which may coexist with metabolic disturbances.Objective and hypotheses: To investigate the role of endocrine disruptor bisphenol A (BPA) in etiopathogenesis of PCOS in adolescent girls. Additionally, we wished to investigate the relationship between BPA and metabolic parameters, insulin re...

hrp0082p2-d1-534 | Puberty and Neuroendocrinology | ESPE2014

Endocrine Disruptors and Polycystic Ovary Syndrome: Phthalates

Akin Leyla , Kendirci Mustafa , Narin Figen , Kurtoglu Selim , Kondolot Meda , Saraymen Recep , Kocak Selda Ozkan , Hatipoglu Nihal , Elmali Ferhan

Background: Polycystic ovary syndrome (PCOS), characterized by hyperandrojenemia, anovulatory periods and polycystic ovaries, is a disorder in which metabolic and reproductive abnormalities overlap. The etiopathogenesis is currently unclarified. Besides the evidence of genetic causes, environmental factors are considered to be involved in development of phenotype. Phthalates are widely used industrial chemicals and have several known untoward effects on human reproductive heal...