hrp0098rfc9.3 | Sex Endocrinology and Gonads | ESPE2024

Nanoencapsulated Curcumin-Piperine Complex: A Breakthrough in Targeting CYP17A1 for Managing Androgen Excess in Adolescents with PCOS.

Yakubu Jibira , Tagit Oya , Natsaridis Evangelos , du Toit Therina , V. Pandey Amit

Androgens play a pivotal role in the pathophysiology of Polycystic Ovary Syndrome (PCOS), a common endocrine disorder affecting adolescent girls. Elevated androgen levels are implicated in the development and progression of PCOS, leading to symptoms such as hirsutism, acne, and irregular menstrual cycles. In patients with PCOS, the inhibition of androgen synthesis presents a therapeutic challenge. Given its crucial role in androgen production, CYP17A1 has become a major target...