hrp0095p1-243 | Diabetes and Insulin | ESPE2022

Did Covid-19 pandemic restrictions impact on diabetic care of children and adolescents in Armenia?

Muradyan Irina , Aghajanova Yelena , Janvelyan Tamara , Markosyan Renata , Bayburdyan Gayane , Kalantaryan Lusine , Arakelyan Lusine , Navasardyan Lusine

Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disorder, which occurs mostly among children and adolescents. Armenia is a middle-low income country, where pediatric diabetic care is given centralized in three main centers. The 85-90% of diabetic children and adolescents are followed in the university hospital. During Covid-19 pandemic Armenia was under either lockdown or strict restrictions. The purpose of the current study is to assess the dynam...

hrp0086p1-p242 | Diabetes P1 | ESPE2016

The Prognostic Role of Non-alcoholic Fatty Liver Disease in Children with Type 1 Diabetes Mellitus with and without Dyslipidemias

Navasardyan Lusine

Background: Recently it is shown that the clinical manifestation of non-alcoholic fatty liver disease (NAFLD) is not related only to liver, but also to cardiovascular complications and mortality. Nowadays there is growing evidence that dyslipidemia and NAFLD association is multisystemic disease, affecting other systems and regulatory pathways. Furthermore, diabetes mellitus worsens the risk of later chronic cardiovascular and atherogenic complications.Ob...

hrp0095p1-54 | Diabetes and Insulin | ESPE2022

Relation between body weight and bone mineral density in type 1 diabetic patients

Ghubatyan Anna , Navasardyan Lusine

Objective(s): Type 1 Diabetes Mellitus (T1DM) is associated with poor bone health. It is shown that the increased fracture risk in T1DM is multifactorial. The aim of current study is to determine the body weight correlation with bone mineral density (BMD) in type 1 diabetic non-obese patients.Materials and Methods: To evaluate the factors associated with bone mineral density in type 1 diabetic patients a total of 45 pati...

hrp0084p3-905 | Fat | ESPE2015

Potential Connection of Dyslipidaemia with BMI and Associated Disorders in Obese Children and Adolescents

Navasardyan Lusine , Markosyan Renata

Background: It is used to define body weight status in children and adolescents using age- and gender-corrected for BMI-SDS. Also excess body weight (EBW) is increasingly applicable to children and adolescents (BMI 99-th percentile). BMI seems to be informative for the severity of obesity, but not for relevant risks of dyslipidaemia.Objective and hypotheses: To reveal the potential connections between absolute levels of lipids and BMI, as well as several...

hrp0094p2-465 | Thyroid | ESPE2021

Allan-Herndon-Dudley syndrome: case report of a rare disorder

Navasardyan Lusine , Muradyan Irina

Introduction: Allan-Herndon-Dudley syndrome (AHDS) is an X linked disorder – mutation of monocarboxylate transporter 8 (MCT8) gene. It leads to a severe psychomotor retardation, significant hypotonia of the skeletal muscles, spastic or dystonic quadriplegia. MCT-8 is responsible for the uptake of T3 by neurons of CNS. AHDS is characterized by increased T3 concentration, increased T3 / T4 ratio, TSH not depressed, even slightly elevated levels. Because of impossibility f...

hrp0095p1-38 | Diabetes and Insulin | ESPE2022

Severe clinical presentation of congenital hyperinsulinism due to newly discovered mutation of HK1: case report

Tumasyan Dalar , Hopkins Jasmin , Flanagan Sarah , Ashotyan Azatuhi , Navasardyan Lusine

Introduction: Congenital hyperinsulinism (CHI) is a disorder of pancreatic beta-cells characterized by inappropriate secretion of insulin leading to hyperinsulinemic hypoglycemia. Insulin secretion is a complex, genetically regulated process. Mutations in several genes known to regulate insulin secretion result in CHI. Recently, non-coding mutations in HK1, which cause the aberrant expression of hexokinase 1 (HK1) in beta cells, have been reported as a novel c...

hrp0092p2-96 | Diabetes and Insulin | ESPE2019

Evaluation of Celiac Disease Antibodies and 25-OH Vitamin D in Type 1 Diabetic Patients

Navasardyan Lusine , Ghubatyan Anna , Arzumanyan Angelina , Gevorgyan Nune , Aghajanova Elena

Background: In diabetic patients vitamin D seems to play a role not only on bone metabolism, but also on many other organs and/or systems, such as lipid profile, cardiovascular system, etc. We decided to evaluate whether the celiac disease antibodies in type 1 diabetic patients have a connection with 25-OH vitamin D status.Materials and Methods: 78 young patients with type 1 diabetes were evaluated with mean age of 14&#1...

hrp0092p3-289 | Late Breaking Abstracts | ESPE2019

Quality of Life of Patients with Type 1 Diabetes

Markosyan Renata , Aghajanova Elena , Navasardyan Lusine , Bayburdyan Gayane

The objective of the study was to evaluate the Pediatric Quality of Life (PedsQL) of children from 8-12 y/o with T1DM, to compare PedsQL perceived by their parents, to understand gender and other factors influence on PedsQL and disease management.We conducted a prospective non-randomized cross-sectional study. Children with T1DM were identified from pediatric endocrinology department registries. The onset of diabetes had to be more than 6 months. All con...

hrp0094p2-49 | Adrenals and HPA Axis | ESPE2021

Assessment of Patients With Congenital Adrenal Hyperplasia in Armenia

Markosyan Renata , Navasardyan Lusine , Bayburdyan Gayane , Aghajanova Yelena ,

The congenital adrenal hyperplasias (CAH) comprise a family of autosomal recessive disorders that disrupt adrenal steroidogenesis.Aim: To investigate the clinical features of the patients with CAH.Methods: The current study was conducted on 106 Armenian patients with CAH.Results: Distribution between regions: 45.3% were from Yerevan, 13.2%-Syunik region, 11.3...

hrp0097p2-187 | Adrenals and HPA Axis | ESPE2023

Challenges and barriers of choosing the sex in patients with congenital adrenal hyperplasia: a case report

Navasardyan Lusine , Tumasyan Dalar , Muradyan Irina , Marutyan Irina , Sarinyan Sofi

Background: Congenital adrenal hyperplasia (CAH) is a disorder, leading to hyperandrogenaemia in the period of organogenesis of external genitalia, resulting in the disorders of sex development(DSD) in 46XX patients where external and internal genitalia do not correspond to each other. The aim of current work is to show the barriers and challenges in a 46XX patient in choosing the sex for up-bringing the child.Case presentation:<...