hrp0095rfc5.4 | Adrenals and HPA Axis | ESPE2022

Increased resting-state functional connectivity in the medial orbitofrontal cortex of patients with autoimmune Addison's disease

van't Westeinde Annelies , Padilla Nelly , Bensing Sophie , Lajic Svetlana

Background: Patients with autoimmune Addison’s disease (AAD) lack production of glucocorticoids (GCs), mineralocorticoids (MCs) and androgens from the adrenal gland, due to autoimmune destruction of its cortex. Patients require replacement of GCs and MCs for the rest of their lives. In some cases, testosterone is supplemented in females. Brain function is sensitive to fluctuations in cortisol and may therefore be affected in AAD due to long-term disturba...

hrp0094p1-5 | Adrenal A | ESPE2021

Alterations in resting-state functional connectivity in patients with congenital adrenal hyperplasia

Messina Valeria , van´t Westeinde Annelies , Padilla Nelly , Lajic Svetlana ,

Background: Patients with congenital adrenal hyperplasia (CAH) are treated with life-long glucocorticoid (GC) replacement therapy. Negative effects on cognition, brain structure and function during working memory tasks have been identified. To date, no studies on functional connectivity during rest have been performed in patients with CAH. One study conducted on patients with CushingÂ’s syndrome, another disorder of cortisol imbalance, suggests that long-t...

hrp0094p1-7 | Adrenal A | ESPE2021

Brain activity during working memory in congenital adrenal hyperplasia

van’t Westeinde Annelies , Zimmermann Marius , Messina Valeria , Karlsson Leif , Padilla Nelly , Lajic Svetlana ,

Objective: Congenital Adrenal Hyperplasia (CAH) requires life-long replacement of cortisol. However, this long-term GC-treatment could change the developmental trajectory of the brain and predispose patients to problems with cognition and mood regulation. Previously, we have found impairments in working memory in patients with CAH, as well as alterations in brain structure in regions of the central executive network (CEN). These changes could be associated wit...