hrp0095fc8.3 | Diabetes and Insulin | ESPE2022

Increased zinc alpha2-glycoprotein in patients with type 1 diabetes

Nourbakhsh Mitra , Nourbakhsh Mona , Golpour Pegah , Momeni Hosein , Razzaghy Azar Maryam

Introduction: Zinc α2-glycoprotein (ZAG) is a single-chain polypeptide with molecular weight of 40-kDa, and is secreted from various tissues. It plays several imperative functions in the human body, such as lipid mobilization and immunoregulation. ZAG enhances lipolysis and is involved in reduction of fatty acids in adipose tissues. ZAG has High sequence similarity to MHC-I molecules and is suggested to be a truncated secretory MHC-I–like protein. ...

hrp0092p2-142 | Fat, Metabolism and Obesity | ESPE2019

Vitamin D Status in Obese Children and its Relationship with Leptin and Adiponectin

Nourbakhsh Mona , Nourbakhsh Mitra , Razzaghy Azar Maryam

Introduction: obesity is a major health problem worldwide and its incidence is increasing annually. Adipose tissue produces and regulates many hormones and cytokines which have relationship with obesity comorbidity. Serum level of vitamin D has been previously reported to have a negative relationship with obesity.Objective: To evaluate the relationship between vitamin D status and leptin, adiponectin, lipid profile and I...

hrp0095p2-120 | Fat, Metabolism and Obesity | ESPE2022

Evaluation of Thyroid Function among children and adolescents with obesity

Nourbakhsh Mona , Ramezani Nastaran , Nourbakhsh Mitra , Razzaghy Azar Maryam

Introduction: Obesity is a rapidly growing health problem, with increasing worldwide prevalence. Obesity is accompanied by numerous metabolic and endocrine dysregulation. Thyroid dysfunction is one of the many metabolic aberrations that are associated with obesity. Thyroid dysfunction can be related to obesity, insulin resistance, and dyslipidemia. We aimed to study the thyroid function in children and adolescents with obesity and the metabolic parameters....

hrp0092p1-341 | Fat, Metabolism and Obesity (2) | ESPE2019

ANGPTL2 and ANGPTL3 in Children with Obesity and Metabolic Syndrome

Azar Maryam Razzaghy , Nourbakhsh Mitra , Sadeghabadi Zahra Arab , Nourbakhsh Mona

Introduction: Angiopoietin-like proteins (ANGPTLs) play critical roles in metabolism and are implicated in metabolic consequences of obesity. ANGPTL2 is a key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance. ANGPTL3 directly regulate lipid, glucose and energy metabolism independent of angiogenic effects. In this study, we aimed to investigate the levels of ANGPTL2 and 3 in obese children and adolescents and their assoc...

hrp0082lbp-d3-1012 | (1) | ESPE2014

Total and Acylated Ghrelin Levels in Children and Adolescents with Growth Retardation

Nourbakhsh Mitra , Latifi Mona , Ilbeygi Davod , Azar Maryam Razzaghy

Background: Ghrelin is a somatotropic and orexigenic protein secreted primarily from stomach.Objective and hypotheses: Since both GH secretion and nutrition, two fundamental contributors in growth promotion, are enhanced by ghrelin, the aim of this study was to investigate the relationship of ghrelin hormone with growth retardation in 3- to 16-year-old children and adolescents and determine whether ghrelin levels are different between normal subjects and...

hrp0092fc4.1 | Fat Metabolism and Obesity Session | ESPE2019

Involvement of Visfatin in Adipose Tissue Fibrosis Through Modulation of Extracellular Matrix Proteins

Nourbakhsh Mitra , Ezzati Mobasser Samira , Malekpour Dehkordi Zahra , Nourbakhsh Mona , Razzaghy Azar Maryam

Introduction: Obesity development and subsequent white adipose tissue (WAT) expansion is often accompanied by WAT fibrosis which leads to adipocyte dysfunction. Fibrosis is a condition in which extracellular matrix (ECM) proteins are increased aberrantly and results in immune cell infiltration, cytokine production and insulin resistance. Visfatin is an adipokine that is implicated in obesity and its metabolic consequences; however, its role in WAT fibrosis has...

hrp0089fc6.6 | Fat, Metabolism and obesity | ESPE2018

MicroRNA-141 Directly Targets and Inhibits Sirtuins 1 Gene Expression and Its Elevation in Obese Subjects is Responsible for Reduced Levels of Sirtuin 1 and the Subsequent Hepatic Steatosis and Insulin Resistance

Nourbakhsh Mitra , Yousefi Zeynab , Nikroo Nikta Dadkhah , Malek Mojtaba , Pazouki Abdolreza , Mokhber Somayye

Introduction: Obesity increases the risk of various disorders including diabetes, non-alcoholic fatty liver disease (NAFLD) and cardiovascular disorders. MicroRNAs (miRNA) are single-stranded, non-coding oligonucleotides that regulate gene expression. Sirtuin 1 (SIRT1), a regulatory enzyme in metabolic homeostasis, is regulated by miRNAs. The aim of this study was to evaluate miR-141 in obesity and whether this miRNA can regulate SIRT1 expression.Materia...

hrp0086p1-p458 | Fat Metabolism and Obesity P1 | ESPE2016

Association of miR-34a and mir-149 with Obesity and Insulin Resistance in Obese Children and Adolescents

Nourbakhsh Mitra , Ahmadpour Fatemeh , Khaghani Shahnaz , Alipour Behnam , Razzaghy Azar Maryam

Background: Obesity is a major public health problem and its rate is increasing worldwide. Obesity accompanies perturbations in metabolism, conferring substantial excess risk for insulin resistance and Type 2 diabetes. Various genetic and epigenetic factors contribute to the development of obesity. MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolis...

hrp0084p2-332 | Fat | ESPE2015

SIRT1 and SIRT2 Gene Expression in Peripheral Blood Mononuclear Cells of Obese Children and Adolescents and their Relationship with Metabolic Parameters and Insulin Resistance

Nourbakhsh Mitra , Razzaghy-Azar Maryam , Arab Zahra , Pasalar Parvin , Golestani Abolfazl , Larijani Bagher

Background: Sirtuins are NAD+-dependant protein deacetylases that target histones, transcription factors, co-regulators, as well as metabolic enzymes to adapt gene expression and metabolic activity in response to the cellular energy state. SIRT1 and SIRT2 are two important enzymes of sirtuin family. SIRT1 has an important role in glucose metabolism and improves glucose homeostasis. It can also regulate fatty acid oxidation and hepatic cholesterol and bile acid metab...

hrp0084p2-364 | Fat | ESPE2015

Evaluation of Acylated Ghrelin and Obestatin Levels and Ghrelin:Obestatin Ratio in Obesity

Razzaghy-Azar Maryam , Nourbakhsh Mitra , Pourmoteabed Abdolreza , Nourbakhsh Mona , Illbeigi Davoud , Arab Zahra

Background: Ghrelin is 28-amino acid peptide predominantly produced by the stomach and have an orexigenic property as well as potent GH-releasing activity. Acylated ghrelin (AG) is the active form of this hormone. Obestatin is a 23-amino acid peptide, is produced by post-translational modification of a protein precursor that also produces ghrelin. Obestatin has the opposite effect of ghrelin on food intake.Objective and hypotheses: To evaluate acylated g...