ESPE Abstracts

Introduction: DKA is the most common cause of hospitalization, morbidity, and death in children with T1DM. Based on the International Society of Pediatric and Adolescent Diabetes (ISPAD) 2022, the biochemical criteria of DKA are: hyperglycemia (blood glucose >200 mg/dL), acidosis (venous pH <7.3 or bicarbonate <18 mmol/L), and ketonemia or moderate/large ketonuria. The principles of ABC (airway, breathing, circulation, and fluid resuscitation) are the...

2Department of Pediatrics, Faculty of Medicine, University of Indonesia, Jakarta, IndonesiaBackground: Short stature is one of the most common findings in Turner syndrome. There are two types of Turner syndrome based on karyotype: classical and mosaic. It is often marked by the body disproportion and dysmorphic profile of the patients. There are still not many data available regarding upper lower body segment ratio (U/L body s...

Background: Parathyroid Hormone (PTH), a key regulator of calcium and phosphorus homeostasis through its effect on bone, kidney, and intestine. The serum concentration of PTH is derived both from the release of PTH stored in secretory granules and from de novo synthesis of PTH in response to alterations in the serum levels of calcium, phosphorus, and vitamin D. Magnesium has a potent role in secretion of PTH, while alkaline phosphatase appears to be important ...

Introduction: Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is a congenital disorder characterized by agenesis or aplasia of the uterus and upper portion of the vagina in females with a normal karyotype (46,XX). Its incidence is approximately 1 in 4,000 to 5,000 live female births. The etiology of MRKH syndrome is highly complex and remains unclear, although genetics is believed to play a significant role in its pathogenesis.Cas...

Introduction: Congenital adrenal hyperplasia (CAH) has an incidence of 1:14 000 to 1:18 000 worldwide. It is caused by autosomal recessive gene mutations. Neonates typically present with virilization at birth, or in shock, ‘salt-losing crisis’, around days 10–14 of life. Some children present later with simple virilizing CAH, often with milder compound heterozygous mutations. Reactive thrombocytosis is a rare manifestation in CAH. Gasparini <...

Introduction: Down Syndrome (DS) is a genetic disorder that has a high mortality rate and a large number of comorbidities such as hypothyroidism and heart disease. Thyroid hormones have significant effects on cardiovascular. This study aims to describe thyroid function and congenital heart defects in Down Syndrome children at dr. Hasan Sadikin General Hospital.Methods: This is a cross-sectional study. The inclusion crite...

Introduction: Magnesium is the second most abundant intracellular cation, and its low level causes several side effects related to hypoparathyroidism, hypocalcaemia, and vitamin D deficiency. Furthermore, some of the cases of hypomagnesemia are linked to platinum-based chemotherapy, resulting in neurotoxicity and nephrotoxicity. Dorsal root ganglion is the main target of platinum drugs, whereby its signs and symptoms can be detected months after chemotherapy. ...