hrp0095fc11.5 | Late Breaking | ESPE2022

Serum kisspeptin, neurokinin B and inhibin B levels can be used as an auxiliary parameter to distinguish idiopathic CPP from premature thelarche in the early stages of puberty

Vuralli Dogus , Ciftci Nurdan , Demirbilek Huseyin

Background: There are controversial results among the results of various studies evaluating diagnostic utility of kisspeptin, NKB, AMH, and INHB for demonstrating activation of hypothalamic-pituitary-gonadal axis in girls with CPP.Aim: To evaluate these 4 neuropeptides in the same individuals who presented with early pubertal signs and their validity in the diagnosis and differential diagnosis of CPP.<p class="abstex...

hrp0095rfc11.5 | Late Breaking | ESPE2022

Dasiglucagon Treatment Over 21 days in Infants with Congenital Hyperinsulinism Results in Glycaemic Stability and Reduces Requirement for Intravenous Glucose

Banerjee Indraneel , D. De Leon Diva , M. Kendall David , Birch Sune , Bøge Eva , Ivkovic Jelena , S Thornton Paul , Nurdan Ciftci , Huseyin Demirbilek

Background: Congenital hyperinsulinism (CHI) is a chronic and complex rare endocrinopathy with dysregulated insulin secretion causing severe and recurrent hypoglycemia resulting in adverse neurologic and developmental sequelae in children. Current treatment options are limited and often inadequate to treat CHI. Dasiglucagon (DASI), a glucagon analog administered by subcutaneous continuous infusion, has demonstrated reduction in glucose infusion rate (GIR) in P...