hrp0095p1-105 | GH and IGFs | ESPE2022

Early Growth Failure and Untreated Growth Hormone Deficiency in Radiotherapy-Treated Long-Term Survivors of Childhood Brain Tumor

Anttonen Julia , Ojaniemi Marja

Growth failure is common in radiotherapy-treated long-term survivors of pediatric brain tumors. The aim of this study was to assess the changes in growth patterns before and after brain tumor diagnosis, the final height, and the risk factors for compromised growth. The incidence and treatment practices of growth hormone deficiency were analyzed.Methods: A cohort of 73 long-term survivors of childhood brain tumor (median age 27.2 years) w...

hrp0095p2-45 | Bone, Growth Plate and Mineral Metabolism | ESPE2022

Adult weight and BMI associate with higher bone mineral density in the lumbar spine and femoral neck in young adults born preterm in the surfactant era

Bruun Ella , Pätsi Pauli , Björkman Krista , Leskinen Markku , Tulppo Mikko , Kulmala Petri , Valkama Marita , Ojaniemi Marja

Background: Vitamin D is a steroid hormone which contributes to the maintenance of calcium homeostasis and bone mineralization. As bone mineral accretion occurs mostly during the third trimester of pregnancy, mineral storages are deficient especially in the extremely low birth weight (ELBW <1000g) preterm infants at birth. Recent studies suggest that ELBW is a risk factor for compromised bone mineral density at adulthood, but the role of neonatal morbidity ...