hrp0092fc4.5 | Fat Metabolism and Obesity Session | ESPE2019

Leptin Gene Methylation Status in Egyptian Infants

Omar Omneya Magdy , Naguib Massoud Mohamed , Elwafa Reham Abo , Gerges Mary

Background: Obesity results from interactions between environmental and genetic factors. Despite a relatively high heritability of common, non-syndromic obesity (40–70%), the search for genetic variants contributing to susceptibility has been a challenging task. To date, more than 40 genetic variants have been associated with obesity and fat distribution. However, since these variants do not fully explain the heritability of obesity, other forms of va...

hrp0089p3-p069 | Bone, Growth Plate & Mineral Metabolism P3 | ESPE2018

Ionized Calcium and 25-Hydroxyvitamin D3 in Children with Steroid-sensitive Nephrotic Syndrome

Abdelmeguid Yasmine Ashraf , Omar Omneya Magdy , Sharaki Ola Atef , Kersh Mahmoud Mohi El-Din El

Introduction: Nephrotic syndrome (NS) is one of the most frequent glomerular pathological conditions seen in children. The International Study of Kidney Disease in Childhood (ISKDC) reported that 84.5% of children with idiopathic nephrotic syndrome (INS) had minimal-change nephrotic syndrome (MCNS). Complications of INS may arise as a result of the disease itself or secondary to treatment. The chief complications of NS are infection, followed by thromboembolic events. Other di...

hrp0089p3-p152 | Fat, Metabolism and Obesity P3 | ESPE2018

Metabolic Endotoxemia in Egyptian Obese Children and Adolescents

Omar Omneya Magdy , Meheissen Marwa , Zaki Basma , Fattah Magdy Abd El

Background: Obesity is associated with metabolic abnormalities, which result in progression to insulin resistance and the metabolic syndrome. The underlying stimulus for these metabolic abnormalities in obesity is not clear, however, recent evidence suggests that systemic, low-level elevations of gut-derived endotoxin (lipopolysaccharide) may play a role in obesity-related metabolic abnormalities.Objective: To study the metabolic endotoxemia in obese chi...