hrp0092p1-265 | Sex Differentiation, Gonads and Gynaecology or Sex Endocrinology (1) | ESPE2019

Dynamics in Blood Pressure After Pubertal Suppression with GnRH Analogs Followed by Testosterone Treatment in Male Adolescents

Perl Liat , Segev-Becker Anat , Israeli Galit , Elkon-Tamir Erella , Weintrob Naomi , Oren Asaf

Background: In 2017, the Endocrine Society published guidelines for the endocrine treatment of gender dysphoria/ gender incongruence. Adolescents who meet diagnostic criteria for gender dysphoria undergo pubertal suppression using gonadotropin-releasing hormone analogs (GnRHa) and induction of puberty with gender-affirming hormonal therapy. Blood pressure (BP) monitoring prior to and during treatment with GnRHa in transgender adolescents is recommended. This r...

hrp0089p2-p023 | Adrenals and HPA Axis P2 | ESPE2018

Adrenal Crisis in Children with Adrenal Insufficiency: Prevalence and Risk Factors

Eyal Ori , Levin Yair , Oren Asaf , Zung Amnon , Rachmiel Marianna , Landau Zohar , Weintrob Naomi

Objectives: To assess the prevalence and risk factors of Adrenal crisis (AC) events in children with Adrenal insufficiency (AI) and to evaluate the effectiveness of the treatment for preventing AC.Methods: Children diagnosed with AI between 1990 and 2017 and treated with glucocorticoids at four pediatric endocrinology units in Israel were studied. Data were retrieved retrospectively from the patientsÂ’ files and they included demographic factors (age...

hrp0084p2-173 | Adrenals | ESPE2015

Normal Ranges of Basal and Glucagon-Stimulated Free Cortisol in Children

Davidov Anita Schachter , Eyal Ori , Anat Anat Becker , Oren Asaf , Stern Naftali , Limor Rona , Weintrob Naomi

Background: Standard assays for serum cortisol measurements determine total cortisol (TC) concentrations but not the unbound biologically active serum free cortisol (sFC). Measurement of TC would be greatly influenced by alteration in cortisol-binding globulin (CBG) concentrations. It is, therefore, important to determine sFC levels when CBG levels are either decreased or increased.Objective and hypotheses: To determine basal and glucagon-stimulated sFC ...

hrp0084p2-318 | DSD | ESPE2015

When, if Ever, Should the Müllerian Remnants be Removed from Subjects with Mixed Gonadal Dysgenesis Raised as Males?

Segev-Becker Anat , Meisler Sarah , Eyal Ori , Oren Asaf , Davidov Anita Schachter , Weintrob Naomi

Background: Mixed gonadal dysgenesis (MGD) is the second most frequent cause of XY disorders of sex development (DSD). Genotype is either X/XY or XY, while the phenotype ranges from partial to complete gonadal dysgenesis, and from female to male external genitalia. Müllerian remnants are present in these patients because of insufficient or untimely foetal secretion of Müllerian inhibiting factor (MIF).Aim: To assess the therapeutic policy of ph...

hrp0095p1-145 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Spatial navigation and memory in transgender male adolescents treated with gender affirming hormones

Perl Liat , Oren Asaf , C. Mueller Sven , Raphael Ido , Borger Ophir , Sheppes Tamar , Shechner Tomer

Background: Spatial navigation is an essential human skill that helps individuals track their changes in position and orientation by integrating self-motion cues. Meta-analyses indicate that males, on average, perform better than females on a number of spatial tasks. Sex steroids, mainly androgens, modulate the remodeling of synapses in the prefrontal cortex and hippocampus, a limbic brain area with critical influence on spatial and contextual memory. Androgen...

hrp0092p1-397 | Pituitary, Neuroendocrinology and Puberty (2) | ESPE2019

Questioning the Value of Brain MRIs in the Evaluation of Children with Isolated Growth Hormone Deficiency

Oren Asaf , Singer Dana , Rachmiel Mariana , Hamiel Uri , Shiran Shelly , Ben-Sira Liat , Schachter-Davidov Anita , Eyal Ori

Background: Isolated growth hormone deficiency (IGHD) is a relatively common disorder. Current diagnostic protocols require a brain MRI of the hypothalamus and the hypophysis after establishment of the diagnosis, with the aim of identifying structural defects and specifically rule out an underlying space-occupying lesion. An MRI scan is costly and requires general anesthesia in young children. Data on the contribution of brain MRI in diagnosing children with I...

hrp0092p2-1 | Adrenals and HPA Axis | ESPE2019

Gender Identity, Sexual Orientation and Quality of Life in Women with Non-classic Congenital Adrenal Hyperplasia

Segev-Becker Anat , Jacobson Roi , Stein Ronnie , Eyal Ori , Oren Asaf , Schachter-Davidov Anita , Israeli Galit , Lebenthal Yael , Joel Daphna , Weintrob Naomi

Context: Higher frequency of atypical gender identity, non-heterosexual fantasies and sexual relationships, and cross-gender role behavior has been reported in females with the more severe salt wasting form of congenital adrenal hyperplasia (CAH). Data on these aspects and quality of life (QOL) among the milder, more prevalent form, the non-classic CAH (NCCAH) is scarce.Objective: To assess gender identity, gender role, ...

hrp0095p1-368 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Gender dimorphism in transgender youth – hormonal therapy and the balance between muscle, adipose tissue and cardiometabolic alterations

Borger Ophir , Oren Asaf , Perl Liat , Yackobovitch-Gavan Michal , Sheppes Tamar , Brener Avivit , Elkon-Tamir Erella , Israeli Galit , Segev-Becker Anat , Lebenthal Ophir Yael

Context: Given the importance of sex hormones in metabolic regulation, dynamics in body composition and cardiometabolic alterations may occur in transgender persons receiving gender-affirming hormone (GAH) therapy.Objectives: Our aim was to explore the association between muscle-to-fat ratio (MFR) and the risk for metabolic syndrome components in transgender youth.Methods: In 71 tr...

hrp0095p1-405 | Adrenals and HPA Axis | ESPE2022

Body composition in children and adolescents with non-classic congenital adrenal hyperplasia and risk for metabolic syndrome components – an observational study

Ben Simon Asaf , Brener Avivit , Segev-Becker Anat , Yackobovitch-Gavan Michal , Uretzky Adi , Schachter Davidov Anita , Oren Asaf , Eyal Ori , Lebenthal Yael

Context: Non-classic congenital adrenal hyperplasia (NCCAH) diagnosed in childhood, whether treated or untreated, could pose an increased risk of obesity and metabolic derangements in adolescence and early adulthood. Both sustained hyperandrogenism and chronic glucocorticoid therapy may affect body composition. However, little is known about the body composition of subjects with NCCAH and its contribution to the development of adverse metabolic outcomes. <...

hrp0095p1-42 | Diabetes and Insulin | ESPE2022

Symptoms and Glycemic Control in Young People with Type 1 Diabetes following SARS-CoV-2 Infection: an Observational Study

Nimri Revital , Rachmiel Marianna , Yackobovitch-Gavan Michal , Brener Avivit , de Vries Liat , Fisch Shvalb Naama , Lazar Liora , Oren Asaf , Jacobi-Polishook Talia , Shefer Averbuch Noa , Tenenbaum Ariel , Mel Eran , Krepel Volsky Sari , Mouler Marie , Demol Sharon , Shalitin Shlomit , Bello Rachel , Phillip Moshe , Lebenthal Yael

Objective: To describe clinical manifestations of SARS-CoV-2 infection in children, adolescents, and young adults with established type 1 diabetes and explore the effects of COVID-19 on glycemic control and disease course.Methods: Observational study conducted at three pediatric diabetes clinics in Israel between mid-March-2020 and mid-March-2021. Included were young people with established type 1 diabetes, <30years, ...