hrp0092p1-144 | Thyroid | ESPE2019

Investigation of Iodine Deficiency in the North of Siberia

Osokina Irina

Introduction: Siberia traditionally belonged to iodine-deficient regions. Cessation of iodine prevention in the 1990-s promoted the increase of iodine deficiency disorders (IDD) in Siberia. For iodine prophylaxis now is used iodized salt, and iodine preparations.The Aim: To estimate the iodine deficiency, the prevalence of IDD and the effectiveness of iodine prophylaxis in the North of Krasnoyarsk territory.<p class=...

hrp0092p1-315 | Diabetes and Insulin (2) | ESPE2019

Immune Status in Children and Adolescents with Type 1 Diabetes

Osokina Irina

Introduction: There are the inconsistent data about a role cellular and humoral immunity in pathogenesis of type 1 diabetes mellitus.The aim: The aim of this research was to study features of the immune status and of the activity of metabolic enzymes in lymphocytes of blood in children with type 1 diabetes.Methods: Cellular and humoral immunity parameters were studied in 94 patient...

hrp0092p3-47 | Diabetes and Insulin | ESPE2019

Serum Catecholamines in Children With Type 1 Diabetes Mellitus

Osokina Irina

Background: young children with type 1 diabetes mellitus (DM1) have a tendency to recurrent hypoglycemia. Increased sensitivity to insulin in young diabetes patients may be associated with features of secretion of catecholamine, particularly adrenaline.The aim: to explore the basal levels of catecholamine (epinephrine, norepinephrine, and dopamine) in serum of young children with type 1 diabetes mellitus to identify of p...

hrp0092p3-58 | Diabetes and Insulin | ESPE2019

Mauriac's Syndrome: A Complication of Poorly Controlled Type 1 Diabetes Mellitus in Childhood and Adolescence

Osokina Irina

Background: Mauriac's syndrome (MS) may occur in patients with poor controlled type 1 diabetes mellitus (DM1), with often ketoacidosis, episodes of hyperglycemia and hypoglycemia, under the dose insulin. MS characterized growth retardation and puberty delay, Cushingoid obesity, moon facies, protuberant abdomen, hepatomegaly with transaminase elevation, dyslipidemia. Now it is a rare syndrome, firstly described by Mauriac in 1930.<str...

hrp0092p3-75 | Diabetes and Insulin | ESPE2019

A 16-Year-Old Girl with Prader-Willi Syndrome and Type 2 Diabetes Mellitus

Osokina Irina

Background: Prader-Willi syndrome (PWS) is a complex genetic disorder with implications on the endocrine and neurologic systems, metabolism, and behavior. Early in life, PWS is characterized by hypotonia and failure to thrive, followed by obesity and hyperphagia. Patients with PWS develop hypothalamic dysfunction which may lead growth hormone deficiency, hypogonadism, hypothyroidism, adrenal insufficiency and poor bone mineral density. Traditionally, obesity i...

hrp0089p3-p104 | Diabetes &amp; Insulin P3 | ESPE2018

The Frequency of Diabetic Ketoacidosis Hospitalization in Siberian Children and Adolescent

Osokina Irina

Introduction: Diabetic ketoacidosis is a frequent reason for hospital admission of children with newly diagnosed diabetes and the most frequent cause for hospitalization of children with poorly controlled diabetes.Aim: To evaluate the frequency of diabetic ketoacidosis (DKA) hospitalization for pediatric patients and resources for its decrease.Methods: Subjects included children <19 years who hospitalized with DKA in the pediat...

hrp0089p3-p304 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

A 2-Year-Old Boy with Epiphysis Tumor and Precocious Puberty

Osokina Irina

Epiphysis inhibits formation and secretion of the most pituitary hormones and at the first turn gonadotropins. Frequency of epiphysis tumors, pinealomas in children is 2.5% of all verified tumors of brain. 75% of epiphysis tumors are malignant. Endocrinological disturbances can be the first signs of pinealoma. In 10% cases there is precocious puberty syndrome. A 2.5 year-old boy presented to the endocrinology department with an 16-month history of accelerated physical developm...

hrp0089p3-p305 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Central Precocious Puberty as a Result of Hypotalamus Hamartoma

Osokina Irina

Presentation of case: A 3-year-old boy with central precocious puberty as a result of the organic lesion of brain (hamartoma of hypotalamus). Complains.Increased height velocity, masculinization, fast growth of external genitalia, frequent erections, acne, low voice. Medical history. The baby was born with weight 3400 g. The age of the mother at birth of the child was 23 years. The breast feeding 6 months. In the age of 24 months boy started to grow very fastly. In the age of ...

hrp0089p3-p306 | Pituitary, Neuroendocrinology and Puberty P3 | ESPE2018

Precocious Puberty as a Result of Ectopic Hormone-Producing Tumor

Osokina Irina

Ectopic hormone products are typical for cancerous cells. Cancerous cells can produce ACTH, lipotropin, alfa-melanocytostimulating hormone, beta-endorfin, vasopressin, oxytocin, insuline, glucagon, gastrin, secretin, VIP, calcitonin, hypothalamic releasing-hormones, prolactin, parathyroid hormone, growth hormone, chorionic gonadotropin, growth factors. In the majority of ectopic hormone-producing tumor cases clinical symptoms are absent. This is explained by the fact that tumo...

hrp0094p2-483 | Thyroid | ESPE2021

A 9-year-old girl with Van Wyk and Grumbach syndrome: precocious puberty as a rare consequence of hypothyroidism

Osokina Irina

Background: The syndrome consisting of primary hypothyroidism, precocious puberty, and massive ovarian cysts was termed Van Wyk and Grumbach syndrome (VWGS) in 1960. Chronic lymphocytic thyroiditis is the more common cause of hypothyroidism in children. In patients with severe longstanding hypothyroidism, the sella turcica may be enlarged due to thyrotrope hyperplasia. Puberty tends to be delayed in hypothyroid children in proportion to the retardation in the bone age, althoug...