hrp0086p2-p322 | Diabetes P2 | ESPE2016

Clinical and Laboratory Characteristics of Children and Adolescents with Type 1 Diabetes Mellitus

Evliyaoglu Olcay , Ercan Oya , Saidov Said

Background: Prevelance of type 1 Diabetes Mellitus is increasing world wide and it is associated with multiple factors.Objective and hypotheses: We aimed to evaluate the clinical and laboratory characteristics of patients with type 1 DM.Method: Clinical records of 184 patients with diabetes (0–18 years) admitted between January 2010 and January 2014 were analysed retrospectively. Age and season at admission, type of admission,...

hrp0097p2-182 | Diabetes and Insulin | ESPE2023

Evaluation of clinical outcomes in children and adolescents with type 1 diabetes switching from Insulin Glargin to Insulin Detemir

Turan Hande , Kaya Didem , Ercan Oya

Basal-bolus insulin therapy is currently, the most common treatment modality in children and adolescents with type 1 diabetes mellitus (T1DM) worldwide. Insulin glargine and detemir are two different molecules, produced with small modifications, of human insulin. In this prospective longitudinal study, we aimed to compare HbA1c, time in range in CGM, basal insulin doses and hypoglyccemia frequencies in children and adolescents with T1DM who underwent switching from insulin det...

hrp0082p2-d2-272 | Adrenals & HP Axis (1) | ESPE2014

Timing of precocious pubarche in girls: Does a contemporary subgroup exist?

Tahmiscioglu Feride , Ercan Oya , Ozcabi Bahar , Evliyaoglu Olcay

Background: In 2012, a phenomenon of early isolated gonadotropin-independent thelarche among contemporary girls was reported.Objective and hypotheses: We wanted to evaluate whether a contemporary isolated early pubarche also exists. One way of looking into this is by investigating the age of pubarche in a group of girls with premature pubarche (PP) over time. If some girls had earlier pubarche, then, we would expect a subgroup (i.e. those younger than 8 ...

hrp0082p2-d2-597 | Thyroid (1) | ESPE2014

Thyroid Nodules in Childhood and Adolescence; Clinical, Radiologic and Etiological Evaluation

Evliyaoglu Olcay , Ozcabi Bahar , Tekin Ayse , Bucak Feride , Ercan Oya

Background: Thyroid nodules are less common in childhood but it has higher risk of malignancy. In this study, we aimed to evaluate children and adolescents with thyroid nodules, clinically, radiologically and histopathologically to determine etiologic distrubution.Method: Seventy-one patients (46 females) with the mean age of 10.41±5.03 (0.04–21) years with thyroid nodules were involved in this study. Patients were evaluated by their complaints...

hrp0095p1-496 | GH and IGFs | ESPE2022

The Effect of Anastrozole Treatment on Height Gain in Pubertal Boys on Growth Hormone Treatment

Tarçın Gürkan , Koç Çalışgan Cansu , Turan Hande , Ercan Oya

Introduction: In children receiving growth hormone (GH) therapy during puberty, epiphyseal fusion due to sex steroids often limits the height gain. Aromatase inhibitors may seem to help at this point despite the lack of evidence. Herein, it was aimed to investigate the efficacy of anastrozole for add-on treatment in pubertal male patients receiving GH therapy.Methods: This is a retrospective study comparing two groups of...

hrp0086p1-p757 | Pituitary and Neuroendocrinology P1 | ESPE2016

Silent Corticotroph Adenoma with Adrenocortical Choristoma in an 11-Years Old Boy

Ercan Oya , Evliyaoglu Olcay , Sinoplu Ada Bulut , Mete Ozgur , Oz Buge

Background: Silent corticotroph adenomas are adenomas composed of corticotrophs but are different from corticotroph adenomas. Despite being silent, they show more aggressive behavior than other clinically nonfunctional adenomas. Adrenocortical choristomas in silent corticotroph adenomas (i.e. the presence of adrenocortical cells in the heterotopic location of the sella) were reported in three patients 16 years or older until now.Objective: Here we report...

hrp0082p2-d3-308 | Bone (2) | ESPE2014

A Case of Vitamin D Dependent Rickets Type 1 with a Novel Mutation in CYP27B1 (25-OH Vitamin D-1-α-Hydroxylase) Gene

Ozcabi Bahar , Evliyaoglu Olcay , Ercan Oya , Tahmiscioglu Feride , Jaferova Sevinc , Oruc Cigdem , Adrovic Amra

Background: Vitamin D dependent type 1 rickets is a rare, autosomal-dominantly inherited disorder due to an inactivating mutation in CYP27B1 (25-OH vitamin D-1-α-hydroxylase) gene. It is characterized by early onset of rickets with hypocalcemia. We report a boy admitted with symptoms of hypocalcemia and who carried a novel mutation in CYP27B1 gene.Case: The patient was admitted with tetany at the age of 12 months. When he had his first convulsion, h...

hrp0084p3-595 | Adrenals | ESPE2015

Three Siblings with Corticosterone Methyloxidase Deficiency Type 2 due to c.1175T>C Mutation +a Novel c.788T>A Mutation in CYP11B2 Gene

Ozcabi Bahar , Evliyaoglu Olcay , Ercan Oya , Bucak Feride Tahmiscioglu , Adrovic Amra , Ceylaner Serdar

Background: Corticosterone methyloxidase deficiency (CMOD) type 2 is an autosomal recessive disorder which presents with salt loss and failure to thrive in early childhood. We present three siblings with CMOD type 2 whose genetic analyses revealed a known c.1175T>C mutation (homozygous) and a novel c.788T>A mutation (homozygous) in CYP11B2 gene.Case 1: The patient was admitted with salt loss and failure to thrive at the age of 6 months; ...

hrp0084p3-935 | GH & IGF | ESPE2015

Do IGF1 Generation Test Results Predict 1st-Year Growth Response to GH Treatment in Idiopathic Short Stature?

Masoom Mohammad Ajmal , Ercan Oya , Bucak Feride Tahmiscioglu , Ozcabi Bahar Taskin , Evliyaoglu Olcay

Background: It is well-known that human GH (hGH) treatment increases growth rate in idiopathic short stature (ISS) in the short term which might predict the overall height gain. However,the fact that ISS might involve a heterogeneous group of individuals with individual benefits from hGH treatment makes the decision to treat or not to treat difficult.Objective and hypotheses: The aim of this study was to investigate retrospectively whether an IGF1 genera...

hrp0094p2-292 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Timing of infancy-childhood growth spurt in healthy Turkish children

Sharifova Sabina , Turan Hande , Tarcin Gurkan , Sharifli Samir , Gur Emel , Ercan Oya ,

Aim: The onset of the infancy-childhood growth spurt (IC spurt) is identical with the onset of the childhood component of the infancy-childhood-puberty growth model. The aim of this study was to determine the timing of IC spurt and to investigate the factors affecting it in healthy children.Materials and Methods: The files of 231 healthy children who were followed up regularly (at 0, 2, 4, 6, 12, 15, 18, 24, 30 and 36 months) at the Ista...