hrp0097p1-574 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2023
Boogers L.S.
, Brüggenwirth H.T.
, van Bever Y.
, Hersmus R.
, Bryce J.
, Ahmed S.F.
, Lucas-Herald A.K.
, Baronio F.
, Cools M.
, Ellaithi M.
, Globa E.
, Güran T.
, Hiort O.
, Holterhus P.M.
, MсElreavey K.
, Niedziela M.
, Stancampiano M.R.
, Tosun B.G.
, Wolffenbuttel K.P.
, Oosterhuis J.W.
, Looijenga L.H.J.
, Hannema S.E.
Introduction: In various forms of XY disorders/differences of sex development (DSD) the risk of germ cell cancer is increased. In the 2006 DSD consensus statement this risk was estimated to be intermediate in 17beta-HSDtype3 deficiency (HSD17B3D) and low in 5alpha-reductasetype2 deficiency (SRD5A2D) but based on very few cases. Few studies have been performed since; therefore we aimed to review gonadal pathology in an international cohort with these conditions...