hrp0097t9 | Section | ESPE2023

Early metabolic risk factors in children with 21 Hydroxylase Deficiency (21OHD): a case-control study

Apuzzo Diletta , Moracas Cristina , Izzo Anna , Di Mase Raffaella , Lorello Paola , Capalbo Donatella , Salerno Mariacarolina

Aims: The balance between hypo/hypercortisolism and hypo/hyperandrogenism is the main challenge in clinical management of patients with 21-hydroxylase deficiency (21OH-D). In adults, it has been established that both over and under-treatment might lead to the development cardiovascular risk factors. To date, only a few studies have addressed weather this risk begins in childhood. Aim of our study is to define the presence of early metabolic risk factors preval...

hrp0092p2-287 | Thyroid | ESPE2019

Bone Homeostasis in Children with Subclinical Hypothyroidism: Effects of Two-years Treatment with Levothyoxine

Barbieri Flavia , Esposito Andrea , D'Acunzo Ida , Lorello Paola , Di Mase Raffaella , Improda Nicola , Capalbo Donatella

Background: Thyroid hormone plays a key role in bone mineral homeostasis and significant alterations in its circulating levels have been associated with an impairment in skeletal growth during childhood. To date, the effects of subclinical hypothyroidism (SH) on bones have not been studied and the management of this condition is still debated.Aim: To evaluate bone mineral density (BMD) in children with mild, persistent S...

hrp0097p1-489 | GH and IGFs | ESPE2023

Effects of GH therapy in patients with GHD (Growth Hormone Deficiency) on glucose homeostasis: results of a 10-years follow-up

Vasaturo Sara , Illiano Sara , Mirra Rita , Lorello Paola , Apuzzo Diletta , Di Mase Raffaella , Capalbo Donatella , Salerno Mariacarolina

Objectives: Among adverse effects of GH, a particular attention should be given to glucose homeostasis. The aim of the study was evaluate the effect of GH therapy on glucose homeostasis in children with GHD after 10 years of treatment.Methods: 30 patients (8 M/22 F, age 7.00 ± 2.61 years) with GHD at diagnosis and 30 healthy children comparable to patients for age, sex and BMI were enrolled. Glucose, insulin, HOMA-IR ...