hrp0092fc5.3 | Thyroid | ESPE2019

Predominant DICER1 Mutations in Pediatric Follicular Thyroid Carcinomas

Ah Lee Young , Im Sun-Wha , Cheon Jung Kyeong , Jae Chung Eun , Ho Shin Choong , Kim Jong-II , Park Young Joo

Background: Pediatric thyroid cancer has characteristics that are distinct from adulthood thyroid cancer. Due to its very low prevalence, little is known about the genetic characteristics of pediatric follicular thyroid cancer (FTC).Methods: We investigated genetic alterations in tumor tissues from 15 patients aged < 20 years (median: 14.3 years; range: 2.4-19.0 years) using multifaceted approaches. Whole-exome seque...

hrp0089p1-p262 | Thyroid P1 | ESPE2018

Subclinical Hypothyroidism, Thyroid Nodule or Cyst in Prepubertal Children: How Many Children were Diagnosed at Age 6?

Lee Young Ah , Cho Sun Wook , Lim Youn-Hee , Kim Johanna Inhyang , Kim Bung-Nyun , Hong Yun-Chul , Park Young Joo , Shin Choong Ho , Yang Sei Won

Purpose: We investigated the prevalence of subclinical hypothyroidism (SCH) and its risk factors in prepubertal children at age 6. We also evaluated the prevalence of thyroid nodule or cyst and its relationship with SCH in prepubertal children.Methods: From the Environment and Development of Children (EDC) cohort study, 458 prepubertal children (243 boys, mean 5.8 years) who visited at age 6 were included in this study. Serum concentrations of free thyro...