hrp0086fc14.6 | Growth : Mechanisms | ESPE2016

In vitro and in vivo Evidence for a Growth Inhibitory Role of the Transcription Factor ZBTB38 Throughout Pre- and Post-Natal Life

Parsons Sam , Stevens Adam , Whatmore Andrew , Murray Philip , Clayton Peter

Background: Single nucleotide polymorphisms (SNPs) within the promotor and 5Â’UTR of the transcriptional factor, ZBTB38, are associated with adult height and idiopathic short stature although their precise auxological effects have not previously been described. In addition, the molecular mechanisms through which ZBTB38 affects growth have not been fully elucidated but potential downstream mediators are suggested to include MCM10 or IGF2.Objectives: <...