hrp0092pl1 | RANKL and RANK: Bone and Beyond | ESPE2019

“RANKL and RANK: Bone and Beyond”

Penninger Josef

RANKL was identified as an osteoclast differentiation factor as well as a T cell-derived stimulator of dendritic cells. The essential role of RANKL in osteoclastogenesis has been genetically proven in both mice and humans. In addition, RANKL was shown to play a critical role in various tissues including the thymus, gut, and mammary gland. The fully human monoclonal antibody against RANKL, denosumab, has been successfully utilized and approved for the treatment of bone metastas...