hrp0098fc8.2 | Adrenals and HPA Axis 2 | ESPE2024

Detection and differentiation of adrenocortical tumors (ACTs) in children by gas chromatography-mass spectrometry (GC-MS) based urinary steroid metabotyping

F Hartmann Michaela , Pons-Kühnemann Joern , Kunstreich Marina , Antje Redlich , Vorwerk Peter , Kuhlen Michaela , A Wudy Stefan

Introduction: ACTs comprise adenomas (ACAs) and carcinomas (ACCs), the latter having a poor prognosis. In children, ACTs are functional and thus symptomatic. We investigated whether GC-MS urinary steroid metabotyping can detect tumors and differentiate between adenomas and carcinomas.Method: We investigated 46 patients (median 6.9; range 0.7-17 yrs; 36 females) with ACTs from the GPOH-MET Study (Registry of the German So...