ESPE Abstracts

Background: Prader-Willi Syndrome (PWS), is a rare complex, genetic neurodevelopmental disorder characterised by hypotonia, poor feeding, neonatal failure to thrive. Untreated, patients progress to hyperphagia and life-limiting extreme obesity. Growth hormone therapy (GHt) is currently the only licenced therapy in PWS. The consensus statement by Deal et al, suggested GH treatment at around 2-years before the onset of obesity. While there are no data to support...

Background and Aims: Infants born prematurely have increased risk of multi-organ dysfunction and death throughout their lives. Males are particularly higher risk and susceptible to the adverse effects of infection related inflammation with poorer clinical outcomes. Immune function, hormone exposure and genetic factors play contributory roles. Physiological concentrations of female hormones hypothesised to have a role in immune development, could affect the exp...