hrp0086rfc10.3 | Perinatal Endocrinology | ESPE2016

Vitamin D Depletion in Pregnancy Decreases Survival Time, Oxygen Saturation, Lung Weight and Body Weight in Preterm Rat Offspring

Lykkedegn Sine , Sorensen Grith Lykke , Beck-Nielsen Signe Sparre , Pilecki Bartosz , Duelund Lars , Marcussen Niels , Christesen Henrik Thybo

Background: Animal studies suggest a role of vitamin D in fetal lung development although not studied in preterm animals.Objective and hypotheses: We tested the hypothesis that vitamin D depletion does not aggravate respiratory insufficiency in preterm rat offspring. Furthermore, the effects of vitamin D depletion on growth and lung surfactant were investigated.Method: Female Sprague-Dawley rats were randomly assigned low vitamin D...