hrp0094p1-167 | Growth B | ESPE2021

Sex differences in growth response to GH treatment: more prepubertal and less pubertal gain in girls diagnosed with IGHD, ISS, SGA. Analysis of data from GH-SAFETY-database, including all children treated with rhGH- 1986-2009 in Sweden, in National-GH-Registry and rhGH-clinical-trials.

Lundberg Elena , Kristrom Berit , Pivodic Aldina , Albertsson-Wikland Kerstin ,

Background: Due to fewer girls than boys being GH-treated, after 50yrs the knowledge about sex-differences in both GH-response and GH-responsiveness before and during puberty remains limited.Aim: To describe factors explaining growth response to GH-treatment, separately in girls and boys from GHstart to adult height (AH).Methods: Children diagnosed with IGHD/ISS/SGA from GH-SAFETY-...

hrp0098rfc5.4 | Growth and Syndromes | ESPE2024

Analysis of growth patterns in Klinefelter syndrome using the QEPS growth model

Holmgren Anton , Niklasson Aimon , Gelander Lars , Nierop Andreas , Pivodic Aldina , Juul Anders , Albertsson-Wikland Kerstin , Aksglaede Lise

Introduction: Klinefelter syndrome (KS, 47XXY) is the most frequent sex chromosome abnormality in males (prevalence 1/667), with tall stature as one of the key characteristics. We aimed to analyse growth patterns during different growth phases and adult height in KS using the QEPS-model.Methods: Longitudinal growth-data from 35 boys with KS followed at a tertiary Danish center for paediatric endocrinology were compared w...