hrp0086p1-p5 | Adrenal P1 | ESPE2016
, Polyzos Alexandros
, Nicolaides Nicolas
, Thanos Dimitris
, Charmandari Evangelia
Background: Primary generalized glucocorticoid resistance (PGGR) is a rare, familial or sporadic condition, characterized by generalized, partial tissue insensitivity to glucocorticoids. The molecular basis of this condition has been ascribed to mutations in the NR3C1 (human glucocorticoid receptor, hGR) gene, which impair the molecular mechanisms of hGR action and decrease tissue sensitivity to glucocorticoids. However, a considerable number of patients with PGGR do ...