hrp0086fc1.5 | Adrenals | ESPE2016

AAV Gene Therapy of 21-Hydroxylase Deficiency (21OHD) in Cyp21−/− mice

Perdomini Morgane , Santos Christine Menguy-Dos , Goumeaux Cyndie , Guidoux Sylvie , Pourcher Guillaume , Aubourg Patrick , Bougneres Pierre

Background: Despite current treatment, girls and women with severe forms of 21OHD are exposed lifelong to a chronic excess of androgens and the secondary effects of suppressive corticoids, which make gene therapy (GT) an option to be explored.Objective: To evaluate the effect of human CYP21 gene transfer mediated by adeno-associated virus (AAV) in a Cyp21−/− mouse model.Methods: 17 adult <em...

hrp0086p1-p448 | Fat Metabolism and Obesity P1 | ESPE2016

Laparoscopic sleeve gastrectomy in adolescents with morbid and dynamic obesity. A controlled monocentric study.

Filippo Gianpaolo De , Pourcher Guillaume , Castell Anne Laure , Kyheng Christele , Bougneres Pierre

Background: Following years of dietary and lifestyle intervention (DLI) as the only therapeutic option, reports of bariatric surgery are emerging in adolescents with morbid obesity. We present herein preliminary results of our 4-yr sleeve gastrectomy study.Objectives and hypotheses: To compare the effects of laparoscopic sleeve gastrectomy (LSG) and intensive DLI in adolescents with morbid obesity (ie BMI >4 DS) and extremely active weight gain (i.e....

hrp0082p2-d2-377 | Fat Metabolism &amp; Obesity (1) | ESPE2014

Short-Term Results of Single-Port Sleeve Gastrectomy in Adolescents with Severe Obesity

De Filippo Gianpaolo , Pourcher Guillaume , Piquard Catherine , Ferretti Stefano , Dagher Ibrahim , Bougneres Pierre

Background: Dietary and lifestyle modifications commonly proposed to overweight or obese youth lack efficacy in those with severe obesity. Early results with bariatric procedures in obese adolescents suggest that weight loss and safety are comparable or better than those seen in adults. One of these procedures, laparoscopic sleeve gastrectomy, is commonly performed using multiple ports. We selected single port sleeve gastrectomy (SPSG) as a minimally invasive surgery to be tes...

hrp0084p2-342 | Fat | ESPE2015

Changes in Insulin Sensitivity in Adolescents Who Underwent Bariatric Surgery: Effects of Laparoscopic Sleeve Gastrectomy and Laparoscopic Gastric Banding

De Filippo Gianpaolo , Pourcher Guillaume , Khen-Dunlop Naziha , Kyheng Christele , Dagher Ibrahim , Bougneres Pierre

Background: In adults, bariatric surgery has gradually emerged as a ‘metabolic’ surgery, able to rapidly improve metabolic disturbances linked to severe obesity. Even if type 2 diabetes is rare in european obese adolescents, alterations in insulin sensitivity are present in almost all.Objective and hypotheses: To evaluate the modification of insulin resistance (IR) and insulin sensitivity (IS) in severe obese adolescents who underwent bariatric...