hrp0086fc13.4 | Management of Obesity | ESPE2016

Efficacy and Safety of Duodenal-Jejunal Bypass Liner in Morbidly Obese Adolescents-1 Year Experience

Kotnik Primoz , Homan Matjaz , Orel Rok , Battelino Tadej

Background: The duodenal-jejunal bypass liner (DJBL) is an endoscopically placed and removable bariatric device associated with weight loss and metabolic improvements in adults.Objective and hypotheses: To determined efficacy and safety of DJBL up to 1 year in morbidly obese adolescents.Method: About 14 obese adolescents with prediabetes or type 2 diabetes (10 female, mean (SD) age 17.7 (1.1) years) underwent endoscopic placement o...

hrp0086p2-p534 | Fat Metabolism and Obesity P2 | ESPE2016

Value of BMI-SDS, Waist Circumference-SDS and Waist-to-Height Ratio in the Identification of Obese Children and Adolescents at an Increased Risk for Cardio-Metabolic Complications

Kovac Jernej , Pavlic Petra , Perdih Brigita , Kotnik Primoz

Background: Determination of obese children/adolescents at an increased risk of cardio-metabolic complications is of paramount significance for early intervention.Objective and hypotheses: To determine the value of simple anthropometric measures of obesity (BMI-SDS, waist circumference (WC)-SDS, waist-to-height ratio (WHR)) in the determination of individuals at an increased risk for selected cardio-metabolic complications (impaired glucose metabolism, d...

hrp0086p1-p613 | Growth P1 | ESPE2016

Glucose Dysregulation in Children with Growth Hormone Deficiency (GHD), Turner Syndrome (TS) or Born Small for Gestational Age (SGA) Treated with GH: A Report from the NordiNet International Outcome Study (IOS)

Kotnik Primoz , Rohrer Tilman , Pedersen Birgitte Tonnes , Pournara Effie , Christesen Henrik

Background: The prevalence of glucose dysregulation in children treated with GH is not well established.Objective and hypotheses: To evaluate the prevalence of glucose dysregulation in children with growth disorders (GH deficiency (GHD), Turner syndrome (TS), small for gestational age (SGA)) treated with GH (Norditropin, Novo Nordisk) enrolled in NordiNet International Outcome Study (IOS) (NCT00960128), a non-interventional study evaluating safety and ef...

hrp0082p2-d2-423 | Growth Hormone (1) | ESPE2014

Normal Onset of Clinical Puberty for Age in GH-Treated Children with Noonan Syndrome or Turner Syndrome: Data from the NordiNet® IOS and ANSWER® Program

Ross Judith , Christesen Henrik , Lee Peter , Germak John , Pedersen Birgitte Tonnes , Kotnik Primoz

Introduction: Noonan syndrome (NS) and Turner syndrome (TS) are distinct genetic disorders with similarities in phenotype, including short stature. The NordiNet® IOS and the ANSWER Program® are observational studies evaluating effectiveness and safety of GH treatment in real-world practice.Methods: The study population included children with NS or TS with puberty recordings, enrolled in NordiNet® IOS or ANS...

hrp0097p1-261 | Fat, Metabolism and Obesity | ESPE2023

Decreased physical fitness in children is associated with increased cardiovascular risk determined by increased carotid intima-media thickness

Drole Torkar Ana , Plesnik Emil , Dovc Klemen , Jazbinsek Soncka , Mlinaric Matej , Groselj Urh , Battelino Tadej , Starc Grogor , Kotnik Primoz

Background: Early vascular aging is driven by modifiable lifestyle risk factors, including physical inactivity. Early identification of children at risk of atherosclerosis (AS) is needed for implementing primary preventive measures addressing vascular health. The aim of the study was to determine the association between objectively determined physical fitness (PF) and carotid intima-media thickness (cIMT), used as a reliable noninvasive biomarker of AS in a po...

hrp0084p2-328 | Fat | ESPE2015

miR-122 and Non-Alcoholic Fatty Liver Disease in Prepubertal Obese Children

Inzaghi Elena , Brandt Stephanie , Roos Julian , Cianfarani Stefano , Nobili Valerio , Colajacomo Mauro , Battelino Tadej , Primoz Kotnik , Wabitsch Martin , Fischer-Posovszky Pamela

Background: The incidence of non-alcoholic fatty liver disease (NAFLD) is dramatically increasing among children worldwide. The gold standard for diagnosis is the liver biopsy. Reliable serum markers are lacking. Recently, circulating miRNAs have been studied as biomarkers of disease progression. Specifically, miR-122 was proposed as predictive marker for liver disease in adults, while no data are available for children.Objective and hypotheses: To inves...

hrp0095p1-16 | Adrenals and HPA Axis | ESPE2022

Long-term follow-up of three male siblings with a novel NNT pathogenic variant causing primary adrenal insufficiency

Kotnik Primoz , Krasovec Tjasa , Sikonja Jaka , Zerjav Tansek Mojca , Debeljak Marusa , Ilovar Sasa , Trebusak Podkrajsek Katarina , Bertok Sara , Tesovnik Tine , Kovac Jernej , Suput Omladic Jasna , F Hartmann Michaela , A Wudy Stefan , Avbelj Stefanija Magdalena , Battelino Tadej , Groselj Urh

Nicotinamide nucleotide transhydrogenase (NNT) is expressed in the heart, thyroid, and testicles, where it maintains the balance of reactive oxygen species in the mitochondria. It is linked, by an insufficiently described mechanism, to primary adrenal insufficiency (PAI) with or without mineralocorticoid insufficiency and several extra-adrenal manifestations (i.e. gonadal adrenal rest tumors, cardiomyopathy, hypothyroidism, and precocious puberty). A comprehensive and chronolo...