ESPE Abstracts

Introduction: In youth, primary ovarian insufficiency (POI) is due to genetic, autoimmune, iatrogenic, and idiopathic etiologies. When POI is diagnosed early with evidence of an ovarian reserve, fertility preservation can be offered. When the girl is premenarchal, the preferred fertility preservation method is ovarian tissue cryopreservation (OTC) containing primordial follicles. In the past, when OTC was performed in an unselected group of children and adoles...

Introduction and aims: The current guidelines for the genetic workup of primary ovarian insufficiency (POI) include performing karyotype and assessing the Fragile X carrier state (FXS). We aimed to investigate the genetic etiologies of POI and assess the need for updated guidelines for POI workup.Methods: We conducted a prospective trial that included individuals with non-iatrogenic, normal karyotype POI, referred to two...