hrp0095p2-52 | Diabetes and Insulin | ESPE2022

Bone and mineral turnover in newly diagnosed children and adolescents with type 1 diabetes mellitus

Slavcheva-Prodanova Olga , Savova Radka , Archinkova Margarita , Konstantinova Maia

Introduction: There is still controversy about the levels of bone turnover markers at type 1 diabetes (T1D) onset and their dynamics at follow-up. Bonfanti et al. did not find any differences at onset, while few months afterwards beta cross laps level was significantly lower. Pater et al. found lower levels of osteocalcin and Log beta cross laps at onset which normalized after 3 and 12 months. Possible mechanisms are metabolic acidosis, decre...

hrp0097p2-169 | Adrenals and HPA Axis | ESPE2023

Von Hippel-Lindau syndrome in a 9-year-old boy

Yaneva Natasha , Archinkova Margarita , Savova Radka , Popova Galina

Background: Von Hippel-Lindau (VHL) syndrome is a rare autosomal dominant genetic disorder characterized by retinal and central nervous system hemangioblastomas, pheochromocytomas and multiple cysts in the pancreas and kidneys, with increased risk of malignant degeneration.Case presentation: A 9-year-old boy with uncomplicated premorbid and family history presented with ice-cold hands and profuse night sweating on the he...

hrp0094p2-109 | Diabetes and insulin | ESPE2021

Clinical Case of Cystic Fibrosis-like and APECED-like Syndrome due to Gain-of-Function Variant in STAT1

Vasilev Teodor , Johnson Matthew , Yaneva Natasha , Slavcheva Olga , Modeva Iskra , Hattersley Andrew , Savova Radka ,

Background: STAT1 mutations can cause an extensive spectrum of disease, varying from severe bacterial and viral infections to mild disseminated mycobacterial disease, also chronic mucocutaneous candidiasis. Many patients present with autoimmune manifestations as type 1 diabetes, hypothyroidism and systemic lupus erythematosus. There are risks of cancers and cerebral aneurysms.Aim: To present the clinical manifes...

hrp0097p1-45 | Diabetes and Insulin | ESPE2023

Common challenges of one uncommon syndrome - single center experience with Congenital Generalized Lipodystrophy

Slavcheva - Prodanova Olga , Archinkova Margarita , Yaneva Natasha , Modeva Iskra , Dimova Ivanka , Savova Radka

Aim: To present some therapeutic difficulties in patients with congenital generalized lipodystrophy (CGL) - a rare autosome recessive disorder characterized by complete absence of adipose tissue. For many years therapy was aimed only at metabolic consequences. In the past few years new pathophysiologic treatment has become available.Methods and materials: We present four girls – currently 25, 22, 16 and 15 years ol...

hrp0095p1-458 | Diabetes and Insulin | ESPE2022

BMI in Bulgarian children and adolescents with type 1 diabetes mellitus – data of two national cross-sectional studies

Archinkova Margarita , Konstantinova Maia , Savova Radka , Iotova Violeta , Kaleva Narcis , Petrova Chaika , Popova Galia , Kundurdzhiev Todor , Witsch Michael , Slavcheva-Prodanova Olga

Pediatric overweight and obesity are also an issue in children and adolescents with type 1 diabetes (T1D). Body Mass Index (BMI) is an accurate and widely used clinical method for assessing childhood obesity.Objective: To analyze the BMI-standard deviation scores (SDS) in Bulgarian children and adolescents with T1D and its relationship with age, gender, type of insulin treatment, and HbAlc.Materials and Met...

hrp0089p1-p076 | Diabetes & Insulin P1 | ESPE2018

National Survey of Usage of Continuous Glucose Monitoring in Children and Adolescents at Non Reimbursed Setting

Bazdarska Yuliya , Iotova Violeta , Mladenov Vilhelm , Boyadzhiev Veselin , Petrova Chayka , Halvadjian Irina , Savova Radka , Popova Galina , Koleva Reni , Moskova Mariyana , Kaleva Nartsis , Nedyalkova Diana

Background: Continuous glucose monitoring (CGM) correlates with optimal control in both children and adults with type 1 diabetes (T1D) regardless of type of treatment. CGM plays a major role in decreasing the time spent in hypoglycemia and hyperglycemia, and achieving better quality of life.Aim: To evaluate the usage and benefits of out-patient CGM and assess parentsÂ’ attitudes to it at a non-reimbursed setting.Methods: A tota...