hrp0097p1-260 | Fat, Metabolism and Obesity | ESPE2023

Early onset obesity due to Melanocortin 4 receptor (MC4R) defect; Successful treatment with Semaglutide

Ramya Gokul Pon , Apperley Louise , Parkinson Jennifer , Seniappan Senthil

Introduction: Childhood obesity is a growing concern worldwide, and it has been linked to several nutritional and genetic factors. In some patients, monogenic causes can be identified, which are due to single gene mutations in specific pathways related to appetite regulation. One of the most common monogenic causes of obesity is heterozygous mutations in Melanocortin 4 receptor (MC4R), with a prevalence ranging from 2% to 6% in juvenile-onset obesity. We repor...

hrp0095rfc3.1 | Early Life and Multisystem Endocrinology | ESPE2022

Brain Magnetic Resonance Imaging Changes in Childhood and its possible correlation with Unrecognised Early Life Hypoglycaemia

Ramya Gokul Pon , Banerjee Indraneel , Ramsden Katie , Worth Chris , Worthington Sarah , Salomon Estebanez Maria

Introduction: The neonatal threshold for hypoglycaemia is debatable and makes its treatment challenging. Neonatal hypoglycaemia can be transient and yet pose a significant risk of neuroglycopaenia, especially with severe and recurrent hypoglycaemia in Congenital Hyperinsulinism. Untreated hypoglycaemia induced cerebral injury can be identified by magnetic resonance (MR) brain scan changes affecting cerebral white matter, occipital lobes and posterior parietote...

hrp0097p1-83 | Fat, Metabolism and Obesity | ESPE2023

Improvement in Health-Related Quality of Life scores in Children and Young people with Obesity following intervention and support from a Tertiary MDT Weight Management Service

Ramya Gokul Pon , Apperley Louise , Parkinson Jennifer , Clarke Ellie , Gubaeva Diliara , Clark Kate , Lund Kim , Owens Meghan , Senniappan Senthil

Introduction: Obesity is a significant public health concern affecting children and young people (CYP) worldwide. The impact of obesity on CYP is multi-faceted and can have a significant effect on their lives. They are at risk of being stigmatized and discriminated against, leading to poor academic performance and social functioning. It is crucial to assess the impact of obesity on the lives of CYP through tools such as Health-related quality of life (HRQOL) q...

hrp0097p2-109 | GH and IGFs | ESPE2023

A real world experience of using Long acting Growth Hormone (Somatrogon) in Children with Growth Hormone Deficiency

Ramya Gokul Pon , Das Urmi , Dharmaraj Poonam , Ramakrishnan Renuka , Didi Mohammed , Blair Jo , Jarvis Charlotte , Laing Peter , Seniappan Senthil

Introduction: Long-acting growth hormone (LaGH) therapy has emerged as a newer treatment option for children with growth hormone deficiency, offering a convenient way of administering growth hormone (GH) injections on a weekly basis. Trials have shown that LaGH formulations are effective in increasing height velocity, improving bone mineral density, and reducing body fat mass in children with Growth hormone deficiency (GHD). The once weekly injections also hav...