hrp0092s2.2 | Novel Mechanisms and Therapies in Bone and Growth Plate: Investing in the Future Health of Children | ESPE2019

Anabolic Therapies for Osteoporosis in Childhood

Rauch Frank

The medical treatment of osteoporosis in children at present mainly relies on anti-resorptive drugs, in particular bisphosphonates. However, not all forms of pediatric osteoporosis are characterized by increased bone resorption. In disorders with low bone turnover and decreased bone formation activity, such as osteoporosis due to neuromuscular disorders and glucocorticoid exposure, use of bone anabolic approaches appears to be a more logical option than antiresorptive drugs, w...

hrp0092rfc6.3 | Bone, Growth Plate and Mineral Metabolism Session 2 | ESPE2019

Increased Burden of Common Risk Alleles in Children with a Significant Fracture History

Manousaki Despoina , Kämpe Anders , Forgetta Vince , Makitie Riikka , Bardai Ghalib , Belisle Alexandre , Li Rui , Makitie Outi , Rauch Frank , Richards Brent

Background: Fractures are common in children, but a significant fracture history, defined as low-trauma vertebral fractures or multiple long bone fractures, is rare. Children with such history and no osteogenesis imperfecta (OI) are often presumed to have another Mendelian disease. However, in adults, multiple common risk alleles of small effect influence risk of fracture. We tested if subjects with a significant childhood fracture history have an increased bu...

hrp0082p2-d1-286 | Bone | ESPE2014

Musculoskeletal Health in Children with Crohn’s Disease at Diagnosis: Dynamic Muscle Function, Tibia Cortical and Trabecular Bone Density and Vertebral Fracture Prevalence

Ward Leanne M , Rauch Frank , Ma Jinhui , Scharke Maya , Cosgrove Heather , Matzinger Mary Ann , Shenouda Nazih , Benchimol Eric I , Mack David R

Background: The bone mass deficit in pediatric Crohn’s disease (CD) is associated with low total body lean mass and suppression of bone turnover.Objective and hypotheses: We examined at diagnosis whether the sarcopenia is associated with leg muscle hypofunction, changes in tibia muscle–bone indices as well as overt bone strength loss (vertebral fractures, VF).Method: 70% children with CD were studied within 2 weeks of dia...