hrp0092p2-142 | Fat, Metabolism and Obesity | ESPE2019

Vitamin D Status in Obese Children and its Relationship with Leptin and Adiponectin

Nourbakhsh Mona , Nourbakhsh Mitra , Razzaghy Azar Maryam

Introduction: obesity is a major health problem worldwide and its incidence is increasing annually. Adipose tissue produces and regulates many hormones and cytokines which have relationship with obesity comorbidity. Serum level of vitamin D has been previously reported to have a negative relationship with obesity.Objective: To evaluate the relationship between vitamin D status and leptin, adiponectin, lipid profile and I...

hrp0086p2-p393 | Gonads & DSD P2 | ESPE2016

Assessment of Sexual Identity in Patients with Congenital Adrenal Hyperplasia

Razzaghy-Azar Maryam , Karimi Sakineh , Shirazi Elham

Background: Congenital adrenal hyperplasia (CAH) is caused by different enzyme deficiency in the pathway of corticosteroid synthesis resulted in disorder of sex development (DSD) and may affect sexual identity in patients.Objective and hypotheses: To assess gender identity in patients with CAH.Method: In this study, 51 patients with CAH [21 children (5–14 years) and 30 adolescents and adults (15–37 years) were assessed us...

hrp0089p3-p210 | GH & IGFs P3 | ESPE2018

A Pilot Study for Comparing Efficacy and Safety of the CinnaTropin® to the Reference Recombinant Human GH in Children with Isolated GH Deficiency and Multiple Pituitary Hormone Deficiency

Razzaghy-Azar Maryam , Pourmotabbed Abdoreza , Heshmat Ramin , Rezaei Farhang

Background: CinnaTropin® (CinnaGen, Iran) is a recombinant human GH manufactured in Iran. Herein, we compared the efficacy and safety of the CinnaTropin® with the corresponding reference (Nordilet® Norditropin, Novo Nordisk, Denmark) in children with idiopathic GH deficiency (IGHD) and multiple pituitary hormone deficiency (MPHD).Methods: This was a randomized, open-label and cross-over study. Eligible pati...

hrp0095p2-120 | Fat, Metabolism and Obesity | ESPE2022

Evaluation of Thyroid Function among children and adolescents with obesity

Nourbakhsh Mona , Ramezani Nastaran , Nourbakhsh Mitra , Razzaghy Azar Maryam

Introduction: Obesity is a rapidly growing health problem, with increasing worldwide prevalence. Obesity is accompanied by numerous metabolic and endocrine dysregulation. Thyroid dysfunction is one of the many metabolic aberrations that are associated with obesity. Thyroid dysfunction can be related to obesity, insulin resistance, and dyslipidemia. We aimed to study the thyroid function in children and adolescents with obesity and the metabolic parameters....

hrp0092fc4.1 | Fat Metabolism and Obesity Session | ESPE2019

Involvement of Visfatin in Adipose Tissue Fibrosis Through Modulation of Extracellular Matrix Proteins

Nourbakhsh Mitra , Ezzati Mobasser Samira , Malekpour Dehkordi Zahra , Nourbakhsh Mona , Razzaghy Azar Maryam

Introduction: Obesity development and subsequent white adipose tissue (WAT) expansion is often accompanied by WAT fibrosis which leads to adipocyte dysfunction. Fibrosis is a condition in which extracellular matrix (ECM) proteins are increased aberrantly and results in immune cell infiltration, cytokine production and insulin resistance. Visfatin is an adipokine that is implicated in obesity and its metabolic consequences; however, its role in WAT fibrosis has...

hrp0086p1-p458 | Fat Metabolism and Obesity P1 | ESPE2016

Association of miR-34a and mir-149 with Obesity and Insulin Resistance in Obese Children and Adolescents

Nourbakhsh Mitra , Ahmadpour Fatemeh , Khaghani Shahnaz , Alipour Behnam , Razzaghy Azar Maryam

Background: Obesity is a major public health problem and its rate is increasing worldwide. Obesity accompanies perturbations in metabolism, conferring substantial excess risk for insulin resistance and Type 2 diabetes. Various genetic and epigenetic factors contribute to the development of obesity. MicroRNAs (miRNAs) are short noncoding RNAs involved in posttranscriptional regulation of gene expression and influence many cellular functions including glucose and lipid metabolis...

hrp0084p2-332 | Fat | ESPE2015

SIRT1 and SIRT2 Gene Expression in Peripheral Blood Mononuclear Cells of Obese Children and Adolescents and their Relationship with Metabolic Parameters and Insulin Resistance

Nourbakhsh Mitra , Razzaghy-Azar Maryam , Arab Zahra , Pasalar Parvin , Golestani Abolfazl , Larijani Bagher

Background: Sirtuins are NAD+-dependant protein deacetylases that target histones, transcription factors, co-regulators, as well as metabolic enzymes to adapt gene expression and metabolic activity in response to the cellular energy state. SIRT1 and SIRT2 are two important enzymes of sirtuin family. SIRT1 has an important role in glucose metabolism and improves glucose homeostasis. It can also regulate fatty acid oxidation and hepatic cholesterol and bile acid metab...

hrp0084p2-364 | Fat | ESPE2015

Evaluation of Acylated Ghrelin and Obestatin Levels and Ghrelin:Obestatin Ratio in Obesity

Razzaghy-Azar Maryam , Nourbakhsh Mitra , Pourmoteabed Abdolreza , Nourbakhsh Mona , Illbeigi Davoud , Arab Zahra

Background: Ghrelin is 28-amino acid peptide predominantly produced by the stomach and have an orexigenic property as well as potent GH-releasing activity. Acylated ghrelin (AG) is the active form of this hormone. Obestatin is a 23-amino acid peptide, is produced by post-translational modification of a protein precursor that also produces ghrelin. Obestatin has the opposite effect of ghrelin on food intake.Objective and hypotheses: To evaluate acylated g...

hrp0094p1-37 | Fat, Metabolism and Obesity A | ESPE2021

The effect of trans-palmitoleic acid on lipid accumulation and the fatty acid synthase gene expression in hepatocytes

Nourbakhsh Mitra , Farokh-Nezhad Ramesh , Razzaghy-Azar Maryam , Sharifi Roya , Yaghmaei Parichehreh , Nourbakhsh Mona ,

Introduction: Obesity is among the most prevalent health problems and is associated with increased risk of various metabolic disorders, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Fatty acids comprise a major part of the lipids and have remarkable effect on cell biology. Trans fatty acids (tFAs) are generally a by-product of manufacturing of fats. However, naturally-produced tFAs that are found in milk and dairy products, are sugge...

hrp0094p2-167 | Diabetes and insulin | ESPE2021

Blood level of Vitamin D and metabolic control of type 1 diabetes mellitus

Razzaghy-Azar Maryam , Nourbakhsh Mona , Nourbakhsh Mitra , Abdiaei Erfan , Abdiaei Hossein ,

Background: There are some studies about vitamin D level and type 1 or type 2 diabetes mellitus (DM). Its effect on metabolic control of patients with type 1 DM is the subject of this study.Patients and Method: In 339 patients with type 1 DM, 192 cases (99 males, 93 females) randomly enrolled in the study. The age of males was 9 ± 4.4 yr and age of females was 8.3±4.3 yr. Their HbA1C and 25(OH) D3 were measured by HPLC method. ...