hrp0098fc4.3 | Adrenals and HPA Axis 1 | ESPE2024

Plasma reference values for C19 oxy-steroids, 11-keto testosterone and 11-keto androstenedione in a paediatric cohort

Kulle Alexandra , Reese Sara , Caliebe Amke , Reinehr Thomas , Simic-Schleicher Gunter , Schulz Esther , Heger Sabine , Holterhus Paul-Martin

Introduction: Rege et al. (2018) demonstrated that 11-keto-testosterone (11KT) is the dominant androgen in girls during adrenarche. Claahsen-van der Grinten et al. (2022) proposed C19 oxysteroids as a potential parameter for therapeutic control in congenital adrenal hyperplasia (CAH). Turcu et al. (2016) observed a significant elevation in C19 oxysteroids in patients with 21-hydroxylase deficiency (21OHD). Currently, C-19 oxysteroids...