hrp0082wg4.2 | Obesity | ESPE2014

Natural Course of Impaired Glucose Tolerance in Obese Children

Reinehr Thomas

Obesity in childhood is associated to several cardiovascular risk factors summarized in the definition of metabolic syndrome such as hypertension, dyslipidemia and impaired glucose tolerance. Besides others, the pathogenetic background is insulin resistance, which deteriorates in mid puberty and normalizes at end of puberty. Accordingly, blood pressure, lipids, fasting glucose and 2 h glucose in oGTT increased from prepubertal stage to pubertal stage and decreased from puberta...

hrp0084wg2.6 | Diabetes Technology and Therapeutics Thursday, 1 October | ESPE2015

Type 2 Diabetes Mellitus in Adolescence

Reinehr Thomas

Type 2 diabetes mellitus (T2DM) is emerging as a new clinical problem within pediatric practice. Recent reports indicate an increasing prevalence of T2DM in children and adolescents around the world in all ethnicities, even if the prevalence of obesity is not increasing any more. There are great differences in T2DM prevalence worldwide. The majority of young people diagnosed with T2DM was found in specific ethnic subgroups such as African-American, Hispanic, Asian/Pacific Isla...

hrp0094pl8 | The long-term effects of adolescent obesity | ESPE2021

The Long term effects of adolescent obesity

Reinehr Thomas

Adolescent obesity has an immense burden of disease and results in premature death due to several mechanisms: The classic cardiovascular risk factors associated with obesity, such as hypertension, dyslipidemia and type 2 diabetes mellitus, lead to cardiovascular diseases and consequently to premature death. Furthermore, adolescent obesity is associated with many life- limiting cancer types occurring 10 to 20 years later replacing smoking as the leading modifiable cause for can...

hrp0092p1-231 | Growth and Syndromes (to include Turner Syndrome) (1) | ESPE2019

Height and Weight Dynamics in Preschool Boys with Constitutional Delay of Growth and Puberty

Reinehr Thomas , Hoffmann Elisa , Rothermel Juliane , Lehrian Thersia , Binder Gerhard

Background: Constitutional delay of growth and puberty (CDGP) is one of the most frequent norm variants in children presenting with short stature. Knowing the height, growth, and weight pattern of CDGP in the first years of life is important to distinguish CDGP from growth hormone deficiency (GHD) or other diseases.Methods: We studied height and weight in the first 5 years of life in 54 boys with CDGP including measureme...

hrp0092p1-380 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

A New Model of Adult Height Prediction Validated in Boys with Constitutional Delay of Growth and Puberty

Reinehr Thomas , Hoffmann Elisa , Rothermel Juliane , Lehrian Theresia , Binder Gerhard

Background: For children with retarded bone ages such as in constitutional delay of growth and puberty (CDGP) there are no specific methods to predict adult height based on bone age. Widely used methods such as Bayley-Pinneau (BP) tend to overestimate adult height in CDGP. Therefore, we aimed to develop a specific adult height prediction model for boys in pubertal age with retarded bone age >1 year.Methods</...

hrp0082p1-d2-153 | Growth (1) | ESPE2014

Intima Media Thickness in Children Treated With GH

Knop Caroline , Wolters Barbara , Lass Nina , Wunsch Rainer , Reinehr Thomas

Background: The cardiovascular risk for children receiving treatment with GH has hardly been investigated. Therefore, we studied the relationships between GH treatment and carotid intima media-thickness (IMT), which is predictive for the cardiovascular diseases.Methods: We measured carotid IMT (four values) in 100 children (mean age 11.6±2.8 years, 63% male) treated with GH (GH deficiency 61%, SGA 31%, Turner syndrome 5%, SHOX deficiency 2%, Prader-...

hrp0084p3-936 | GH &amp; IGF | ESPE2015

Adherence to GH Treatment: Impact of Actual Height, Treatment Duration, and Puberty

Rothermel Juliane , Scheite Karl , Nazari Nadine , Hauffa Berthold , Reinehr Thomas

Background: Adherence to GH treatment is a challenge.Objective and hypotheses: We analysed the impact of treatment duration, treatment success, treatment indication, age, gender, pubertal stage, and height on treatment adherence (TA) to optimise treatment success.Method: Based on the easypod autoinjector used in the Saizen-online prospective, multicenter, open-label, noninterventional study we analyzed TA in 6 months periods. TA wa...

hrp0092p1-379 | Growth and Syndromes (to include Turner Syndrome) (2) | ESPE2019

Adult Height Prediction by Bone Age Determination in Children with Idiopathic Growth Hormone Deficiency (IGHD): Analysis of KIGS Data

Reinehr Thomas , Carlsson Martin , Chrysis Dionisios , Camacho-Hübner Cecilia

Background: The precision of adult height prediction by bone age determination in children with idiopathic growth hormone deficiency (IGHD) is unknown.Patients and Methods: The near adult height (NAH) of patients with IGHD with prepubertal onset of growth hormone treatment (GH) in the KIGS database was compared to adult height prediction based on bone ages (BA) >7 years using the Bailey Pinneau (BP) or Tanner-Whiteho...

hrp0086rfc13.4 | Management of Obesity | ESPE2016

Which Amount of BMI-SDS Reduction is Necessary to Improve Cardiovascular Risk Factors in Overweight and Obese Children?

Reinehr Thomas , Lass Nina , Toschke Christina , Rothermel Juliane , Lanzinger Stefanie , Holl Reinhard

Background: Knowing the changes of cardiovascular risk factors (CRF) in relation to weight loss would be helpful to advise overweight children and their parents and to decide whether drugs should be prescribed in addition to lifestyle intervention.Objective and hypotheses: The aim of the study was to determine the degree of overweight reduction to improve CRFs in overweight children.Method: We studied changes of blood pressure (BP)...

hrp0086p1-p804 | Syndromes: Mechanisms and Management P1 | ESPE2016

Near-Adult Height in a Large Cohort of Patients with Turner Syndrome and Noonan Syndrome Treated with rhGH: Results from Pfizer International Growth Database

Ranke Michael , Lindberg Anders , Camacho-Hubner Cecilia , Reinehr Thomas , Rooman Raoul

Background: Pfizer International Growth Database (KIGS) contains data of Turner syndrome (TS; N=7378) or Noonan syndrome (NS; N=613, female=224; male=389) patients who were treated with rhGH.Objective: To compare the effect of rhGH on near adult height (NAH) in TS and NS patients. We hypothesized a similar outcome in both diagnoses. Determinants of the treatment outcome in NS patients were also assessed.Patients a...