hrp0086p1-p471 | Fat Metabolism and Obesity P1 | ESPE2016

Improved Clinical and Laboratory Changes after 12 Months of Use of Metformin in Obese Insulin Resistant Children and Adolescents

Cominato Louise , Rocha Ruth , Renie Oliveira Rachid Ludmilla , Filgueiras Vilaca Duarte Nathalia , Cinquini Freitas Franco Natalia , Ybarra Marina , Steinmetz Leandra , Damiani Durval

Background: Childhood obesity is one of the most prevalent and challenging health care concerns. In this context, insulin resistance (IR) is an important disorder with strong association with metabolic (type 2 diabetes, hypercholesterolemia) and cardiovascular (hypertension, atherosclerosis) outcomes. Clinical trials have been showing Metformin as an effective drug on reducing the IR and BMI. However, there is little data on use of metformin in children....