ESPE Abstracts

Background: A reduction in bone mass in adults and adolescents has been observed following Roux-en-Y bypass surgery with an increase in fracture risk reported in adults. However, the intragastric balloon (IGB) is a less invasive bariatric procedure.Objective and hypotheses: Given obese adolescents are at greater risk of fracture we studied the impact of a 6 month IGB insertion on skeletal mass, geometry and strength over 2 years.Me...

Background: Bone mass is low in obese children when measured by conventional techniques. However, these imaging modalities cannot quantify alterations in bone microstructure and strength. High resolution peripheral quantitative computed tomography (HRpQCT – isotropic voxel size 82 mm) provides the resolution required to determine 3-dimensional in-vivo bone microstructure; microfinite element (microFE) analysis of HRpQCT images provides insight into skeletal biome...

Background: The current screening test for adrenal insufficiency (AI) involves patients traveling to attend hospital for an “early” morning serum cortisol (EMC) sample, generally taken some considerable time after the child has woken. This risks missing the morning cortisol peak, leading to false positive results and necessitating further testing, usually by the Short Synacthen Test (SST). Both EMC and SST require venepuncture, which is resource in...